G-protein signaling: Satisfying the basic necessities of life

被引:16
作者
Wilkie, TM [1 ]
机构
[1] Univ Texas, SW Med Ctr, Dept Pharmacol, Dallas, TX 75390 USA
关键词
D O I
10.1016/S0960-9822(00)00823-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Recent studies have shed light on the role of G-protein signaling, and in particular the regulatory RGS proteins, in behavioral adaptations of the round worm Caenorhabditis elegans; similar signaling pathways underlie analogous physiology and behaviors in mammals.
引用
收藏
页码:R853 / R856
页数:4
相关论文
共 29 条
[1]   Leptin [J].
Ahima, RS ;
Flier, JS .
ANNUAL REVIEW OF PHYSIOLOGY, 2000, 62 :413-437
[2]   Sst2 is a GTPase-activating protein for Gpa1:: Purification and characterization of a cognate RGS-Gα protein pair in yeast [J].
Apanovitch, DM ;
Slep, KC ;
Sigler, PB ;
Dohlman, HG .
BIOCHEMISTRY, 1998, 37 (14) :4815-4822
[3]   Lifetime regulation of G protein-effector complex: Emerging importance of RGS proteins [J].
Arshavsky, VY ;
Pugh, EN .
NEURON, 1998, 20 (01) :11-14
[4]   Sorting and storage during secretory granule biogenesis: looking backward and looking forward [J].
Arvan, P ;
Castle, D .
BIOCHEMICAL JOURNAL, 1998, 332 :593-610
[5]   GAIP and RGS4 are GTPase-activating proteins for the G(i) subfamily of G protein alpha subunits [J].
Berman, DM ;
Wilkie, TM ;
Gilman, AG .
CELL, 1996, 86 (03) :445-452
[6]   Identification of the Gβ5-RGS7 protein complex in the retina [J].
Cabrera, JL ;
de Freitas, F ;
Satpaev, DK ;
Slepak, VZ .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 249 (03) :898-902
[7]   Narcolepsy in orexin knockout mice:: Molecular genetics of sleep regulation [J].
Chemelli, RM ;
Willie, JT ;
Sinton, CM ;
Elmquist, JK ;
Scammell, T ;
Lee, C ;
Richardson, JA ;
Williams, SC ;
Xiong, YM ;
Kisanuki, Y ;
Fitch, TE ;
Nakazato, M ;
Hammer, RE ;
Saper, CB ;
Yanagisawa, M .
CELL, 1999, 98 (04) :437-451
[8]   Slowed recovery of rod photoresponse in mice lacking the GTPase accelerating protein RGS9-1 [J].
Chen, CK ;
Burns, ME ;
He, W ;
Wensel, TG ;
Baylor, DA ;
Simon, MI .
NATURE, 2000, 403 (6769) :557-560
[9]   RGS proteins and signaling by heterotrimeric G proteins [J].
Dohlman, HG ;
Thorner, J .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (07) :3871-3874
[10]   Calcium oscillations increase the efficiency and specificity of gene expression [J].
Dolmetsch, RE ;
Xu, KL ;
Lewis, RS .
NATURE, 1998, 392 (6679) :933-936