Clozapine and risperidone treatment of psychosis in Parkinson's disease

被引:117
作者
Ellis, T [1 ]
Cudkowicz, ME [1 ]
Sexton, PM [1 ]
Growdon, JH [1 ]
机构
[1] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA
关键词
D O I
10.1176/appi.neuropsych.12.3.364
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The authors compared efficacy and safety of risperidone and clozapine for the treatment of psychosis in a double-blind trial with 10 subjects with Parkinson's disease (PD) and psychosis, Mean improvement in the Brief Psychiatric Rating Scale psychosis score was similar in the clozapine and the risperidone groups (P = 0.23). Although the mean motor Unified Parkinson's Disease Rating Scale score worsened in the risperidone group and improved in the clozapine group, this difference did not reach statistical significance. One subject on clozapine developed neutropenia. In subjects with PD, risperidone may be considered as an alternative to clozapine because it is as effective for the treatment of psychoses without the hematologic, antimuscarinic, and seizure Sine effects. However, risperidone may worsen extrapyramidal symptoms more than clozapine and therefore must be used with caution.
引用
收藏
页码:364 / 369
页数:6
相关论文
共 36 条
[1]   THE POSITIVE AND NEGATIVE SYNDROME SCALE AND THE BRIEF PSYCHIATRIC RATING-SCALE - RELIABILITY, COMPARABILITY, AND PREDICTIVE-VALIDITY [J].
BELL, M ;
MILSTEIN, R ;
BEAMGOULET, J ;
LYSAKER, P ;
CICCHETTI, D .
JOURNAL OF NERVOUS AND MENTAL DISEASE, 1992, 180 (11) :723-728
[2]  
BORISON RL, 1992, PSYCHOPHARMACOL BULL, V28, P213
[3]  
Breier AF, 1999, AM J PSYCHIAT, V156, P294
[4]  
CHOUINARD G, 1993, J CLIN PSYCHOPHARM, V13, P25
[5]  
CHOUINARD G, 1993, CAN J PSYCHIAT, V38, P89
[6]   RISPERIDONE VERSUS HALOPERIDOL IN THE TREATMENT OF CHRONIC-SCHIZOPHRENIC INPATIENTS - A MULTICENTER DOUBLE-BLIND COMPARATIVE-STUDY [J].
CLAUS, A ;
BOLLEN, J ;
DECUYPER, H ;
ENEMAN, M ;
MALFROID, M ;
PEUSKENS, J ;
HEYLEN, S .
ACTA PSYCHIATRICA SCANDINAVICA, 1992, 85 (04) :295-305
[7]   INTERRATER RELIABILITY OF THE BLESSED DEMENTIA SCALE [J].
COLE, MG .
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE, 1990, 35 (04) :328-330
[8]   CLOZAPINE - A 2-YEAR OPEN TRIAL IN PARKINSONS-DISEASE PATIENTS WITH PSYCHOSIS [J].
FACTOR, SA ;
BROWN, D ;
MOLHO, ES ;
PODSKALNY, GD .
NEUROLOGY, 1994, 44 (03) :544-546
[9]   CLOZAPINE PREVENTS RECURRENCE OF PSYCHOSIS IN PARKINSONS-DISEASE [J].
FACTOR, SA ;
BROWN, D .
MOVEMENT DISORDERS, 1992, 7 (02) :125-131
[10]  
Fahn S., RECENT DEV PARKINSON, V2, P153, DOI DOI 10.1002/ANA.410220556