Identification of a sex steroid-inducible gene in the neonatal rat hypothalamus

被引：60

作者：

Suzuki, M ^{[1
]}

Yoshida, S ^{[1
]}

Nishihara, M ^{[1
]}

Takahashi, M ^{[1
]}

机构：

[1] Univ Tokyo, Dept Vet Physiol, Bunkyo Ku, Tokyo 113, Japan

来源：

NEUROSCIENCE LETTERS | 1998年 / 242卷 / 03期

基金：

日本学术振兴会;

关键词：

cDNA subtraction; sex steroid-induced gene expression; granulin; sexual dimorphism; ventromedial nucleus of the hypothalamus; arcuate nucleus;

D O I：

10.1016/S0304-3940(98)00008-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

By the cDNA subtraction between cDNA preparations from androgenized and intact neonate rats hypothalami, granulin/epithelin (grn) gene was identified as a gene enriched by androgenization. Strong grn mRNA signals were detected by in situ hybridization in the ventromedial nucleus (VMH) and the arcuate nucleus (ARC) of the hypothalamus of a 5-day-old male. The grn gene expression level in the hypothalamus was similar between males and females at birth. At 10 days of age, this level was maintained in males, but decreased to 1/4 in females. Thus, grn can be the gene of which expression in the VMH and ARC is sustained by endogenous androgen in male neonates. (C) 1998 Elsevier Science Ireland Ltd.

引用

页码：127 / 130

页数：4

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