Asymmetric diene cyclization/hydrosilylation/oxidation employing 1-tert-butyl-3,3-dimethyl-1,1-diphenyldisiloxane

被引：16

作者：

Pei, T ^{[1
]}

Widenhoefer, RA ^{[1
]}

机构：

[1] Duke Univ, PM Gross Chem Lab, Durham, NC 27708 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 40期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(00)01321-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A 1:1 mixture of (N-N)Pd(Me)Cl [N-N = (R)-(+)-4-isopropyl-2-(2-pyridinyl)-2-oxazoline] (1) and NaBAr4 [Ar = 3,5-C6H3(CF3)(2)] catalyzed the asymmetric cyclization/hydrosilylation of functionalized 1,6-dienes with 1-tert-butyl-3,3-dimethyl-1,1-diphenyldisiloxane at -20 degrees C to form silylated cyclopentanes in good yield with up to 95% ee. These silylated carbocycles underwent oxidative cleavage of the C-Si bond with H2O2 at room temperature to form the corresponding alcohols. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：7597 / 7600

页数：4

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