LIF inhibits osteoblast differentiation at least in part by regulation of HAS2 and its product hyaluronan

被引：27

作者：

Falconi, Dominic

Aubin, Jane E.

机构：

[1] Univ Toronto, Dept Mol & Med Genet, Toronto, ON M5S 1A8, Canada

[2] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2007年 / 22卷 / 08期

关键词：

leukemia inhibitory factor; osteoblast; differentiation; differential display; hyaluronan synthase 2;

D O I：

10.1359/JBMR.070417

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

LIF arrests osteogenesis in fetal rat calvaria cells in a differentiation stage-specific manner. Differential display identified HAS2 as a LIF-induced gene and its product, HA, modulated osteoblast differentiation similarly to LIF. Our data suggest that LIF arrests osteoblast differentiation by altering HA content of the extracellular matrix.

引用

收藏

页码：1289 / 1300

页数：12

相关论文

共 81 条

[1]

AKAO Y, 1995, CANCER RES, V55, P3444

[2]

Mice deficient in small leucine-rich proteoglycans:: novel in vivo models for osteoporosis, osteoarthritis, Ehlers-Danlos syndrome, muscular dystrophy, and corneal diseases [J].

Ameye, L ;

Young, MF .

GLYCOBIOLOGY, 2002, 12 (09) :107R-116R

[3]

Aubin JE, 1999, J CELL BIOCHEM, V72, P396, DOI 10.1002/(SICI)1097-4644(19990301)72:3<396::AID-JCB9>3.0.CO

[4]

2-6

[5]

HMG CoA reductase inhibitors and the skeleton: a comprehensive review [J].

Bauer, DC .

OSTEOPOROSIS INTERNATIONAL, 2003, 14 (04) :273-282

[6]

MINERALIZED BONE NODULES FORMED INVITRO FROM ENZYMATICALLY RELEASED RAT CALVARIA CELL-POPULATIONS [J].

BELLOWS, CG ;

AUBIN, JE ;

HEERSCHE, JNM ;

ANTOSZ, ME .

CALCIFIED TISSUE INTERNATIONAL, 1986, 38 (03) :143-154

[7]

The leucine-rich repeat protein PRELP binds perlecan and collagens and may function as a basement membrane anchor [J].

Bengtsson, E ;

Mörgelin, M ;

Sasaki, T ;

Timpl, R ;

Heinegård, D ;

Aspberg, A .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (17) :15061-15068

[8]

Leukemia inhibitory factor and oncostatin M influence the mineral phases formed in a murine heterotopic calcification model: A Fourier transform infrared microspectroscopic study [J].

Bohic, S ;

Rohanizadeh, R ;

Touchais, S ;

Godard, A ;

Daculsi, G ;

Heymann, D .

JOURNAL OF BONE AND MINERAL RESEARCH, 1998, 13 (10) :1619-1632

[9]

CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration [J].

Bourguignon, LYW ;

Zhu, HB ;

Shao, LJ ;

Chen, YW .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (10) :7327-7336

[10]

Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (Macrophage-Colony stimulating factor) production and breast tumor progression [J].

Bourguignon, LYW ;

Singleton, PA ;

Zhu, HB ;

Diedrich, F .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (32) :29420-29434

← 1 2 3 4 5 6 7 8 9 →