Horizontal cells of the primate retina: Cone specificity without spectral opponency

被引:180
作者
Dacey, DM
Lee, BB
Stafford, DK
Pokorny, J
Smith, VC
机构
[1] MAX PLANCK INST BIOPHYS CHEM,D-37077 GOTTINGEN,GERMANY
[2] UNIV CHICAGO,CTR VISUAL SCI,CHICAGO,IL 60637
关键词
D O I
10.1126/science.271.5249.656
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The chromatic dimensions of human color vision have a neural basis in the retina. Ganglion cells, the output neurons of the retina, exhibit spectral opponency; they are excited by some wavelengths and inhibited by others. The hypothesis that the opponent circuitry emerges from selective connections between horizontal cell interneurons and cone photoreceptors sensitive to long, middle, and short wavelengths (L-, M-, and S-cones) was tested by physiologically and anatomically characterizing cone connections of horizontal cell mosaics in macaque monkeys. H1 horizontal cells received input only from L- and M-cones, whereas H2 horizontal cells received a strong input from S-cones and a weaker input from L- and M-cones. All cone inputs were the same sign, and both horizontal cell types lacked opponency. Despite cone type selectivity, the horizontal cell cannot be the locus of an opponent transformation in primates, including humans.
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页码:656 / 659
页数:4
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