Macaque model for severe acute respiratory syndrome

被引：95

作者：

Rowe, T

Gao, GP

Hogan, RJ

Crystal, RG

Voss, TG

Grant, RL

Bell, P

Kobinger, GP

Wivel, NA

Wilson, JM

机构：

[1] So Res Inst, Homeland Secur & Emerging Infect Dis Res Div, Birmingham, AL 35255 USA

[2] Univ Penn, Dept Med, Div Med Genet, Gene Therapy Program, Philadelphia, PA 19104 USA

[3] Cornell Univ, Weill Med Coll, Dept Med Genet, New York, NY USA

来源：

JOURNAL OF VIROLOGY | 2004年 / 78卷 / 20期

关键词：

D O I：

10.1128/JVI.78.20.11401-11404.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Rhesus and cynomolgus macaques were challenged with 10(7) PFU of a clinical isolate of the severe acute respiratory syndrome (SARS) coronavirus. Some of the animals developed a mild self-limited respiratory infection very different from that observed in humans with SARS. The macaque model as it currently exists will have limited utility in the study of SARS and the evaluation of therapies.

引用

页码：11401 / 11404

页数：4

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