Immunodominant minor histocompatibility antigens: the major ones

被引：59

作者：

Perreault, C

Roy, DC

Fortin, C

机构：

[1] Hop Maison Neuve Rosemont, Res Ctr, Quebec City, PQ H1T 2M4, Canada

[2] Univ Laval, Ecole Psychol, Quebec City, PQ G1K 7P4, Canada

来源：

IMMUNOLOGY TODAY | 1998年 / 19卷 / 02期

关键词：

D O I：

10.1016/S0167-5699(97)01185-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Minor histocompatibility antigens (MiHAs) are extremely numerous - possibly up to 720 in mice - and have been regarded as an 'immunogenetic nightmare' in transplantation. Here, Claude Perreault, Denis Roy and Claudette Fortin summarize evidence showing that most anti-MiHA T-cell responses are oligoclonal, being restricted to several dominant MiHAs, rather than polyclonal. This concept has important implications in transplantation and cancer immunotherapy.

引用

页码：69 / 74

页数：6

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