Induction of tolerance by Porphyromonas gingivalis on APCs:: a mechanism implicated in periodontal infection

被引：36

作者：

Cohen, N

Morisset, J

Emilie, D

机构：

[1] Inst Paris Sud Cytokines, INSERM, U131, F-92140 Clamart, France

[2] Fac Med Dent, Dept Oral Biol, F-75006 Paris, France

来源：

JOURNAL OF DENTAL RESEARCH | 2004年 / 83卷 / 05期

关键词：

Porphyromonas gingivalis; ILT-3; B7-H1; IL-10;

D O I：

10.1177/154405910408300515

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

The periodontal pathogen Porphyromonas gingivalis (Pg) is a potent inducer of the production of pro-inflammatory cytokines by neutrophils, monocytes, and macrophages, and can desensitize immune cells in vitro and in vivo. We analyzed the ability of Pg lipopolysaccharide (LPS) to induce endotoxin tolerance. Treatment of dendritic cells ( DC), the human macrophage cell line THP-1, and monocytes (antigen-presenting cells, APC) with Pg. LPS inhibited APC maturation assessed by CD80 and CD86 expression, and inhibited chemokine (CCL3 and CCL5) production. Pre-treatment with glucocorticoids ( GC) and interleukin-10 (IL-10) abolished the effect of Pg. LPS on CD80, CD83, and CD86, and on CCL3 and CCL5 production. We also showed that Pg. LPS enhanced the tolerogenic properties of APCs and up-regulated ILT-3 and B7-H1 expression.

引用

收藏

页码：429 / 433

页数：5

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