Acetogenic isoquinoline alkaloids.: Part 140 -: Ancistrolikokines A-C:: New 5,8′-coupled naphthylisoquinoline alkaloids from Ancistrocladus likoko

被引:27
作者
Bringmann, G
Günther, C
Saeb, W
Mies, J
Wickramasinghe, A
Mudogo, V
Brun, R
机构
[1] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany
[2] Univ Kinshasa, Fac Sci, Kinshasa, DEM REP CONGO
[3] Univ Peradeniya, Dept Chem, Peradeniya, Sri Lanka
[4] Schweizer Tropeninst, CH-4002 Basel, Switzerland
来源
JOURNAL OF NATURAL PRODUCTS | 2000年 / 63卷 / 10期
关键词
D O I
10.1021/np000199t
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Three new naphthylisoquinoline alkaloids, ancistrolikokines A-C (1-3), have been isolated and structurally assigned from Ancistrocladus likoko, as well as the known compound korupensamine A (4). Their 5,8'-coupling hints at a close biogenetic relationship of A. likoko to other Central African Ancistrocladus species. Compounds 1-4 showed good to moderate antimalarial activities when evaluated in vitro against the NF54 and K1 strains of Plasmodium falciparum.
引用
收藏
页码:1333 / 1337
页数:5
相关论文
共 17 条
[1]   ANTI-HIV MICHELLAMINES FROM ANCISTROCLADUS-KORUPENSIS [J].
BOYD, MR ;
HALLOCK, YF ;
MANFREDI, KP ;
BLUNT, JW ;
MCMAHON, JB ;
BUCKHEIT, RW ;
BRINGMANN, G ;
SCHAFFER, M ;
CRAGG, GM ;
THOMAS, DW ;
JATO, JG ;
CARDELLINA, JH .
JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (12) :1740-1745
[2]  
Bringmann G, 1999, MAGN RESON CHEM, V37, P98, DOI 10.1002/(SICI)1097-458X(199902)37:2<98::AID-MRC428>3.0.CO
[3]  
2-I
[4]   First atropo-divergent total synthesis of the antimalarial korupensamines A and B by the "lactone method" [J].
Bringmann, G ;
Ochse, M ;
Götz, R .
JOURNAL OF ORGANIC CHEMISTRY, 2000, 65 (07) :2069-2077
[5]   Ancistroguineines A and B as well as ancistrotectorine-naphthylisoquinoline alkaloids from Ancistrocladus guineensis [J].
Bringmann, G ;
Günther, C ;
Busemann, S ;
Schäffer, M ;
Olowokudejo, JD ;
Alo, BL .
PHYTOCHEMISTRY, 1998, 47 (01) :37-43
[6]   Acetogenic isoquinoline alkaloids part 136 -: 8-O-methyldioncophyllinol B and revised structures of other 7,6′-coupled naphthylisoquinoline alkaloids from Triphyophyllum peltatum (Dioncophyllaceae) [J].
Bringmann, G ;
Günther, C ;
Saeb, W ;
Mies, J ;
Brun, R ;
Assi, LA .
PHYTOCHEMISTRY, 2000, 54 (03) :337-346
[7]   ACETOGENIC ISOQUINOLINE ALKALOIDS .66. FIRST TOTAL SYNTHESIS OF KORUPENSAMINE-A AND KORUPENSAMINE-B [J].
BRINGMANN, G ;
GOTZ, R ;
KELLER, PA ;
WALTER, R ;
HENSCHEL, P ;
SCHAFFER, M ;
STABLEIN, M ;
KELLY, TR ;
BOYD, MR .
HETEROCYCLES, 1994, 39 (02) :503-508
[8]   An improved degradation procedure for determination of the absolute configuration in chiral isoquinoline and beta-carboline derivatives [J].
Bringmann, G ;
God, R ;
Schaffer, M .
PHYTOCHEMISTRY, 1996, 43 (06) :1393-1403
[9]  
Bringmann G., 1995, ALKALOIDS, V46, P127
[10]  
BRINGMANN G, 2000, ACT CHIM THERAPEUT, V26, P151