Acetogenic isoquinoline alkaloids.: Part 140 -: Ancistrolikokines A-C:: New 5,8′-coupled naphthylisoquinoline alkaloids from Ancistrocladus likoko

被引：27

作者：

Bringmann, G

Günther, C

Saeb, W

Mies, J

Wickramasinghe, A

Mudogo, V

Brun, R

机构：

[1] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany

[2] Univ Kinshasa, Fac Sci, Kinshasa, DEM REP CONGO

[3] Univ Peradeniya, Dept Chem, Peradeniya, Sri Lanka

[4] Schweizer Tropeninst, CH-4002 Basel, Switzerland

来源：

JOURNAL OF NATURAL PRODUCTS | 2000年 / 63卷 / 10期

关键词：

D O I：

10.1021/np000199t

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new naphthylisoquinoline alkaloids, ancistrolikokines A-C (1-3), have been isolated and structurally assigned from Ancistrocladus likoko, as well as the known compound korupensamine A (4). Their 5,8'-coupling hints at a close biogenetic relationship of A. likoko to other Central African Ancistrocladus species. Compounds 1-4 showed good to moderate antimalarial activities when evaluated in vitro against the NF54 and K1 strains of Plasmodium falciparum.

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页码：1333 / 1337

页数：5

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