New directions in single-molecule imaging and analysis

被引：347

作者：

Moerner, W. E. ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2007年 / 104卷 / 31期

关键词：

biophysics; microscopy; superresolution; trapping; FLUORESCENCE CORRELATION SPECTROSCOPY; ALTERNATING-LASER EXCITATION; 3-DIMENSIONAL SUPERRESOLUTION; PENTACENE MOLECULES; LIVING CELLS; LIVE CELLS; MICROSCOPY; PROTEIN; RESOLUTION; LOCALIZATION;

D O I：

10.1073/pnas.0610081104

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Optical imaging and analysis of single molecules continue to unfold as powerful ways to study the individual behavior of biological systems, unobscured by ensemble averaging. Current expansion of interest in this field is great, as evidenced by new meetings, journal special issues, and the large number of new investigators. Selected recent advances in biomolecular analysis are described, and two new research directions are summarized: superresolution imaging using single-molecule fluorescence and trapping of single molecules in solution by direct suppression of Brownian motion.

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收藏

页码：12596 / 12602

页数：7

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