α-Glucosidase inhibitory pentacyclic triterpenes from the stem bark of Fagara tessmannii (Rutaceae)

被引：81

作者：

Mbaze, Luc Meva'a

Poumale, Herve Martial P.

Wansi, Jean Duplex

Lado, Jean Alexandre

Khan, Shamsun Nahar

Iqbal, Muhammad Choudhary

Ngadjui, Bonaventure Tchaleu

Laatsch, Hartmut

机构：

[1] Univ Douala, Fac Sci, Dept Chem, Douala, Cameroon

[2] Univ Gottingen, Dept Organ & Biomol Chem, D-37077 Gottingen, Germany

[3] Univ Yaounde, Fac Sci, Dept Organ Chem, Yaounde, Cameroon

[4] Univ Karachi, HEJ Res Inst Chem, Karachi 75270, Pakistan

来源：

PHYTOCHEMISTRY | 2007年 / 68卷 / 05期

关键词：

Fagara tessmannii; Rutaceae; pentacyclic triterpene; antifungal; antibacterial; alpha-glucosidase inhibition;

D O I：

10.1016/j.phytochem.2006.12.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

in addition to fatty acids, a mixture of sterols (beta-sitosterol, stigmasterol, campesterol and stigmastanol), lupeol, arctigenin methylether, sesamin, vanillic acid (1), 2,6-dimethoxy-1,4-benzoquinone (2), betulinic acid and two pentacyclic triterpene acetates were isolated from Fagara tessmannii Engl. They were identified as 30-acetoxy-16 beta-hydroxybetulinic acid (3a) and 3 beta,16 beta-diacetoxybetulinic acid (3b), and their structures were established using 1 and 2D NMR spectra and by comparison with published data. Two derivatives of the compounds were prepared. Some isolated compounds were evaluated for their antifungal and antibacterial activities. Compounds 1 and 3a showed significant inhibition of alpha-glucosidase. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：591 / 595

页数：5

共 14 条

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Influence of year and planting date on fatty acid chemistry of high oleic acid and normal peanut genotypes [J].