Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle

被引:350
作者
Le Roch, KG
Johnson, JR
Florens, L
Zhou, YY
Santrosyan, A
Grainger, M
Yan, SF
Williamson, KC
Holder, AA
Carucci, DJ
Yates, JR
Winzeler, EA
机构
[1] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA
[2] Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
[3] Natl Inst Med Res, Div Parasitol, London NW7 1AA, England
[4] USN, Med Res Ctr, Malaria Program IDD, Silver Spring, MD 20910 USA
[5] Loyola Univ, Dept Biol, Chicago, IL 60626 USA
基金
英国医学研究理事会;
关键词
D O I
10.1101/gr.2523904
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
To investigate the role of post-transcriptional controls in the regulation of protein expression for the malaria parasite, Plasmodium falciparum, we have compared mRNA transcript and protein abundance levels for seven different stages of the parasite life cycle. A moderately high positive relationship between mRNA and protein abundance was observed for these stages; the most common discrepancy was a delay between mRNA and protein accumulation. Potentially post-transcriptionally regulated genes are identified, and families of functionally related genes were observed to share similar patterns of mRNA and protein accumulation.
引用
收藏
页码:2308 / 2318
页数:11
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