Polyamines inhibit lipopolysaccharide-induced nitric oxide synthase activity in rat liver cytosol

被引:22
作者
Blachier, F
Mignon, A
Soubrane, O
机构
[1] INRA, Unite Ecol & Physiol Syst Digestif, F-78352 Jouy En Josas, France
[2] INSERM, Fac Med Cochin, F-75014 Paris, France
[3] Hop Cochin, Lab Rech Chirurg, F-75014 Paris, France
来源
NITRIC OXIDE-BIOLOGY AND CHEMISTRY | 1997年 / 1卷 / 03期
关键词
D O I
10.1006/niox.1997.0127
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Liver cells can produce nitric oxide from L-arginine through either constitutive NO synthase or inducible NO synthase (NOS) detected after in vivo or in vitro treatment with cytokines and/or lipopolysaccharide (LPS). The effects of NO on liver cells are associated with protein synthesis and mitochondrial electron transfer inhibition. L-Arginine is also the precursor of L-ornithine and polyamines. The latter are considered to be protective in the Liver in several experimental models. The aim of the present work was to test the effects of polyamines on LPS-inducible NOS activity in rat liver cytosol using the test of radioactive L-citrulline synthesis from L-[guanido-C-14]arginine. The three polyamines inhibited inducible NO synthase activity with the following hierarchy: spermine > spermidine approximate to putrescine. The 0.5 mM spermine was found to inhibit 50% of inducible NO synthase activity. The present data suggest an inhibitory interrelationship in the liver between two metabolites derived from the common precursor L-arginine. (C) 1997 Academic Press.
引用
收藏
页码:268 / 272
页数:5
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