Glucagon-like peptide-2, but not glucose-dependent insulinotropic polypeptide, stimulates glucagon release in patients with type 1 diabetes

被引:21
作者
Christensen, Mikkel [1 ]
Knop, Filip K. [1 ]
Vilsboll, Tina [1 ]
Aaboe, Kasper [1 ,2 ]
Holst, Jens J. [2 ]
Madsbad, Sten [3 ]
Krarup, Thure [4 ]
机构
[1] Univ Copenhagen, Gentofte Hosp, Dept Internal Med F, DK-2900 Hellerup, Denmark
[2] Univ Copenhagen, Panum Inst, Dept Biomed Sci, DK-2900 Hellerup, Denmark
[3] Univ Copenhagen, Hvidovre Hosp, Dept Endocrinol, DK-2900 Hellerup, Denmark
[4] Univ Copenhagen, Bispebjerg Hosp, Dept Endocrinol, DK-2900 Hellerup, Denmark
关键词
Glucagon-like peptide-2 (GLP-2); Glucose-dependent insulinotropic polypeptide (GIP); Incretin effect; Glucagon; Type 1 diabetes mellitus; Diabetes; Alpha cell; GASTRIC-INHIBITORY POLYPEPTIDE; ALPHA-CELL-FUNCTION; POSTPRANDIAL HYPERGLYCEMIA; RAT PANCREAS; ORAL GLUCOSE; MELLITUS; SECRETION; SUPPRESSION; HEALTHY; HUMANS;
D O I
10.1016/j.regpep.2010.05.004
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This study investigated the glucagon-releasing properties of the hormones glucagon-like peptide-2 (GLP-2) and glucose-dependent insulinotropic polypeptide (GIP) in 8 patients with type 1 diabetes mellitus (T1DM) without paracrine intraislet influence of insulin (C-peptide negative following a 5 g intravenous arginine stimulation: on study days only treated with basal insulin substitution) On 3 study days, 180-minute two-step glucose clamps were performed. Plasma glucose (PG) was clamped at fasting values, with a mean of 74 +/- 05 mM in the first 90 min (period 1) and raised 1.5 times the fasting values to a mean of 11.1 +/- 0 1 mM in the last 90 min (period 2) In randomised order either GIP, GLP-2. or saline were infused intravenously during first 50 min in both periods at rates designed to mimic postprandial hormone responses The resulting incremental area under curve values of glucagon were in period 1-38 +/- 44 (GIP), 120 +/- 48 (GLP-2), and -16 +/- 61 (saline) pM x 90 min (p = 0.087), respectively, and in period 2-157 +/- 76, 135 +/- 52, and -77 +/- 77 pM x 90 min (p = 0019), respectively Post hoc analysis showed significant differences only between the GLP-2 days versus the GIP and saline days In conclusion, GLP-2, but not GIP, was found to stimulate the release of glucagon in patients with T1DM, suggesting a role for GLP-2 in the postprandial hyperglucagonaemia characterising individuals with T1DM (C) 2010 Elsevier B.V. All rights reserved
引用
收藏
页码:96 / 101
页数:6
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