Aurora kinases in spindle assembly and chromosome segregation

被引：160

作者：

Ducat, D

Zheng, YX

机构：

[1] Carnegie Inst Sci, Howard Hughes Med Inst, Dept Embryol, Baltimore, MD 21210 USA

[2] Johns Hopkins Univ, Dept Biol, Baltimore, MD 21218 USA

来源：

EXPERIMENTAL CELL RESEARCH | 2004年 / 301卷 / 01期

关键词：

aurora kinase; mitosis; centrosome; spindle; chromosome segregation; centromere; kinetochore;

D O I：

10.1016/j.yexcr.2004.08.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Aurora kinase family consists of three members, Aurora A, B, and C. The Aurora A and B kinases have emerged as essential regulators of cell division. While Aurora A kinase is implicated in regulating mitotic entry, centrosome maturation, and spindle assembly, Aurora B is required for correct chromosome segregation and cytokinesis. In this review, we summarize the roles of Aurora A and B in spindle assembly and chromosome segregation. (C) 2004 Published by Elsevier Inc.

引用

收藏

页码：60 / 67

页数：8

相关论文

共 58 条

[1] Chromosomal passengers and the (aurora) ABCs of mitosis [J].

Adams, RR ;

Carmena, M ;

Earnshaw, WC .

TRENDS IN CELL BIOLOGY, 2001, 11 (02) :49-54

[2] Aurora B regulates MCAK at the mitotic centromere [J].

Andrews, PD ;

Ovechkina, Y ;

Morrice, N ;

Wagenbach, M ;

Duncan, K ;

Wordeman, L ;

Swedlow, JR .

DEVELOPMENTAL CELL, 2004, 6 (02) :253-268

[3] Structural basis of Aurora-A activation by TPX2 at the mitotic spindle [J].

Bayliss, R ;

Sardon, T ;

Vernos, I ;

Conti, E .

MOLECULAR CELL, 2003, 12 (04) :851-862

[4] TAC-1 and ZYG-9 form a complex that promotes microtubule assembly in C-elegans embryos [J].

Bellanger, JM ;

Gönczy, P .

CURRENT BIOLOGY, 2003, 13 (17) :1488-1498

[5] Drosophila aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis [J].

Berdnik, D ;

Knoblich, JA .

CURRENT BIOLOGY, 2002, 12 (08) :640-647

[6] The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the, spindle checkpoint [J].

Biggins, S ;

Murray, AW .

GENES & DEVELOPMENT, 2001, 15 (23) :3118-3129

[7] Phosphorylation of the carboxyl terminus of inner centromere protein (INCENP) by the Aurora B kinase stimulates Aurora B kinase activity [J].

Bishop, JD ;

Schumacher, JM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (31) :27577-27580

[8] Survivin is required for stable checkpoint activation in taxol-treated HeLa cells [J].

Carvalho, A ;

Carmena, M ;

Sambade, C ;

Earnshaw, WC ;

Wheatley, SP .

JOURNAL OF CELL SCIENCE, 2003, 116 (14) :2987-2998

[9] Implication of a novel multiprotein Dam1p complex in outer kinetochore function [J].

Cheeseman, IM ;

Brew, C ;

Wolyniak, M ;

Desai, A ;

Anderson, S ;

Muster, N ;

Yates, JR ;

Huffaker, TC ;

Drubin, DG ;

Barnes, G .

JOURNAL OF CELL BIOLOGY, 2001, 155 (07) :1137-1145

[10] Mitotic spindle integrity and kinetochore function linked by the Duo1p/Dam1p complex [J].

Cheeseman, IM ;

Enquist-Newman, M ;

Müller-Reichert, T ;

Drubin, DG ;

Barnes, G .

JOURNAL OF CELL BIOLOGY, 2001, 152 (01) :197-212

← 1 2 3 4 5 6 →