Vaccination of langur monkeys (Presbytis entellus) against Leishmania donovani with autoclaved L. major plus BCG

被引：43

作者：

Dube, A

Sharma, P

Srivastava, JK

Misra, A

Naik, S

Katiyar, JC

机构：

[1] Cent Drug Res Inst, Div Parasitol, Lucknow 226001, Uttar Pradesh, India

[2] Sanjay Gandhi Postgrad Inst Med Sci, Dept Immunol, Lucknow 226014, Uttar Pradesh, India

来源：

PARASITOLOGY | 1998年 / 116卷

关键词：

Leishmania major; BCG; L-donovani; Indian langur monkeys; cross-protection; vaccination;

D O I：

10.1017/S0031182097002175

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The protective potential of killed Leishmania major (ALM) along with BCG was evaluated against L. donovani in Indian langur monkeys in single and triple dose schedules. A delayed protection was observed in monkeys after a single dose schedule of ALM (3 mg)+BCG (3 mg) given intradermally 2 months before intravenous challenge with L. donovani. Triple dose schedule each of 1 mg ALM+1 mg BCG was more effective. The status remained unchanged until the end of the experiment (approximately 8 months). The study indicates that a combination of ALM+BCG may be a good candidate vaccine for exploiting against human Kala-azar.

引用

页码：219 / 221

页数：3

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