Asymmetric synthesis of both enantiomers of α,α-difluoroeldanolide:: An interesting property of their biological activity

被引：29

作者：

Itoh, T ^{[1
]}

Sakabe, K

Kudo, K

Zagatti, P

Renou, M

机构：

[1] Okayama Univ, Fac Educ, Dept Chem, Okayama 7008530, Japan

[2] INRA, Unite Phytopharm & Mediateurs Chim, F-78026 Versailles, France

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 23期

关键词：

D O I：

10.1016/S0040-4039(98)00661-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of difluorinated analogue of an insect sex pheromone has been accomplished through intramolecular radical cyclization and lipase-catalyzed reaction. Optically active alpha,alpha-difluoroeldanolide and its antipode have been synthesized. Dose-response curves constructed from electroantennogram responses of female moths showed the difluoroanalogues to be-as active as the natural pheromone. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：4071 / 4074

页数：4

共 23 条

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