Immune recognition of self in immunity against cancer

被引：100

作者：

Houghton, AN ^{[1
]}

Guevara-Patiño, JA ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Swim Arcross Amer Lab Tumor Immunol, New York, NY 10021 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2004年 / 114卷 / 04期

关键词：

D O I：

10.1172/JCI200422685

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Most antigens expressed by human cancer cells and recognized by host T cells and antibodies are nonmutated self antigens - molecules also expressed on the surface of normal cells. These self antigens are ineffective at triggering immune responses against cancer cells, which provides one explanation for the difficulties in trying to immunize against human cancer. A new study describes how tumors can avoid recognition by the immune system and how enhancing the affinity of the interaction between a self antigen and the MHC-I molecule may lead to cancer immunity (see the article beginning on page 551).

引用

页码：468 / 471

页数：4

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