Pathways of tau fibrillization

被引：106

作者：

Kuret, J ^{[1
]}

Chirita, CN ^{[1
]}

Congdon, EE ^{[1
]}

Kannanayakal, T ^{[1
]}

Li, GB ^{[1
]}

Necula, M ^{[1
]}

Yin, HS ^{[1
]}

Zhong, Q ^{[1
]}

机构：

[1] Ohio State Univ, Coll Med & Publ Hlth, Dept Mol & Cellular Biochem, Ctr Mol Neurobiol, Columbus, OH 43210 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2005年 / 1739卷 / 2-3期

关键词：

Alzheimer's disease; neurofibrillary tangle; tau; folding intermediate; aggregation; kinetics;

D O I：

10.1016/j.bbadis.2004.06.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New methods for analyzing tau fibrillization have yielded insights into the biochemical transitions involved in the process. Here we review the parallels between the sequential progression of tau fibrillization observed macroscopically in Alzheimer's disease (AD) lesions and the pathway of tau aggregation observed in vitro with purified tau preparations. In addition, pharmacological agents for further dissection of fibrillization mechanism and lesion formation are discussed. (C) 2004 Elsevier B.V All rights reserved.

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收藏

页码：167 / 178

页数：12

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