Actin' up: RhoB in cancer and apoptosis

被引：184

作者：

Prendergast, GC ^{[1
]}

机构：

[1] Dupont Merck Pharmaceut Co, Glenolden Lab, Glenolden, PA 19004 USA

[2] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

来源：

NATURE REVIEWS CANCER | 2001年 / 1卷 / 02期

关键词：

D O I：

10.1038/35101096

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

RhoB is a small GTPase that regulates actin organization and vesicle transport. It is required for signalling apoptosis in transformed cells that are exposed to farnesyltransferase inhibitors, DNA-damaging agents or taxol. Genetic analysis in mice indicates that RhoB is dispensable for normal cell physiology, but that it has a suppressor or negative modifier function in stress-associated processes, including cancer.

引用

页码：162 / 168

页数：7

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