A mutant of Listeria monocytogenes LO28 unable to induce an acid tolerance response displays diminished virulence in a murine model

被引：46

作者：

Marron, L

Emerson, N

Gahan, CGM

Hill, C

机构：

[1] NATL UNIV IRELAND UNIV COLL CORK,DEPT MICROBIOL,CORK,IRELAND

[2] NATL UNIV IRELAND UNIV COLL CORK,NATL FOOD BIOTECHNOL CTR,CORK,IRELAND

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 1997年 / 63卷 / 12期

关键词：

D O I：

10.1128/AEM.63.12.4945-4947.1997

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Exposing Listeria monocytogenes LO28 to sublethal pH induces protection against normally lethal pH conditions, a phenomenon known as the acid tolerance response. We identified a mutant, L. monocytogenes ATR1, which is incapable of inducing such tolerance, either against low pH or against any other stress tested. The virulence of this mutant was considerably decreased, suggesting that the acid tolerance response contributes to in vivo survival of L. monocytogenes.

引用

页码：4945 / 4947

页数：3

共 6 条

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