Lipopolyamines incorporating the tetraamine spermine, bound to an alkyl chain, sequester bacterial lipopolysaccharide

被引：32

作者：

Blagbrough, IS ^{[1
]}

Geall, AJ

David, SA

机构：

[1] Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England

[2] Univ Kansas, Med Ctr, Dept Microbiol Immunol & Mol Genet, Kansas City, KS 66160 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(00)00380-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Lipopolyamines, with high affinity for calf thymus DNA in an ethidium bromide displacement assay, bind with high affinity to bacterial lipopolysaccharide and neutralise in vitro endotoxic activity as determined by Griess nitric oxide and TNF-alpha ELISA assays. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1959 / 1962

页数：4

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