ARE THERE DELETERIOUS CARDIAC EFFECTS OF ACUTE AND CHRONIC ENDURANCE EXERCISE?

被引:175
作者
Eijsvogels, Thijs M. H.
Fernandez, Antonio B.
Thompson, Paul D.
机构
[1] Hartford Hosp, Dept Cardiol, Hartford, CT 06115 USA
[2] Radboud Univ Nijmegen, Med Ctr, Dept Physiol, NL-6525 ED Nijmegen, Netherlands
关键词
BRAIN NATRIURETIC PEPTIDE; CORONARY-ARTERY CALCIFICATION; PROLONGED STRENUOUS EXERCISE; LEFT-VENTRICULAR FUNCTION; TROPONIN-T RELEASE; DISEASE-SPECIFIC MORTALITY; HEART-ASSOCIATION COUNCIL; AORTIC ROOT SIZE; LONG-QT SYNDROME; PHYSICAL-ACTIVITY;
D O I
10.1152/physrev.00029.2014
中图分类号
Q4 [生理学];
学科分类号
071003 [生理学];
摘要
Multiple epidemiological studies document that habitual physical activity reduces the risk of atherosclerotic cardiovascular disease (ASCVD), and most demonstrate progressively lower rates of ASCVD with progressively more physical activity. Few studies have included individuals performing high-intensity, lifelong endurance exercise, however, and recent reports suggest that prodigious amounts of exercise may increase markers for, and even the incidence of, cardiovascular disease. This review examines the evidence that extremes of endurance exercise may increase cardiovascular disease risk by reviewing the causes and incidence of exercise-related cardiac events, and the acute effects of exercise on cardiovascular function, the effect of exercise on cardiac biomarkers, including "myocardial" creatine kinase, cardiac troponins, and cardiac natriuretic peptides. This review also examines the effect of exercise on coronary atherosclerosis and calcification, the frequency of atrial fibrillation in aging athletes, and the possibility that exercise may be deleterious in individuals genetically predisposed to such cardiac abnormalities as long QT syndrome, right ventricular cardiomyopathy, and hypertrophic cardiomyopathy. This review is to our knowledge unique because it addresses all known potentially adverse cardiovascular effects of endurance exercise. The best evidence remains that physical activity and exercise training benefit the population, but it is possible that prolonged exercise and exercise training can adversely affect cardiac function in some individuals. This hypothesis warrants further examination.
引用
收藏
页码:99 / 125
页数:27
相关论文
共 296 条
[1]
Is the risk of atrial fibrillation higher in athletes than in the general population? A systematic review and meta-analysis [J].
Abdulla, Jawdat ;
Nielsen, Jens Rokkedal .
EUROPACE, 2009, 11 (09) :1156-1159
[2]
Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo [J].
Aikawa, Elena ;
Nahrendorf, Matthias ;
Figueiredo, Jose-Luiz ;
Swirski, Filip K. ;
Shtatland, Timur ;
Kohler, Rainer H. ;
Jaffer, Farouc A. ;
Aikawa, Masanori ;
Weissleder, Ralph .
CIRCULATION, 2007, 116 (24) :2841-2850
[3]
Relation of Vigorous Exercise to Risk of Atrial Fibrillation [J].
Aizer, Anthony ;
Gaziano, J. Michael ;
Cook, Nancy R. ;
Manson, Joann E. ;
Buring, Julie E. ;
Albert, Christine M. .
AMERICAN JOURNAL OF CARDIOLOGY, 2009, 103 (11) :1572-1577
[4]
Triggering of sudden death from cardiac causes by vigorous exertion [J].
Albert, CM ;
Mittleman, MA ;
Chae, CU ;
Lee, IM ;
Hennekens, CH ;
Manson, JE .
NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (19) :1355-1361
[5]
B-type natriuretic peptide is related to left ventricular mass in hypertensive patients but not in athletes [J].
Almeida, SS ;
Azevedo, A ;
Castro, A ;
Frioes, F ;
Freitas, J ;
Ferreira, A ;
Bettencourt, P .
CARDIOLOGY, 2002, 98 (03) :113-115
[6]
Myocardial infarction redefined -: A consensus document of the Joint European Society of Cardiology/American College of Cardiology Committee for the Redefinition of Myocardial Infarction [J].
Alpert, JS ;
Antman, E ;
Apple, F ;
Armstrong, PW ;
Bassand, JP ;
de Luna, AB ;
Beller, G ;
Breithardt, G ;
Chaitman, BR ;
Clemmensen, P ;
Falk, E ;
Fishbein, MC ;
Galvani, M ;
Garson, A ;
Grines, C ;
Hamm, C ;
Hoppe, U ;
Jaffe, A ;
Katus, H ;
Kjekshus, J ;
Klein, W ;
Klootwijk, P ;
Lenfant, C ;
Levy, D ;
Levy, RI ;
Luepker, R ;
Marcus, F ;
Näslund, U ;
Ohman, M ;
Pahlm, O ;
Poole-Wilson, P ;
Popp, R ;
Pyörälä, K ;
Ravkilde, J ;
Rehnquist, N ;
Roberts, W ;
Roberts, R ;
Roelandt, J ;
Rydén, L ;
Sans, S ;
Simoons, ML ;
Thygesen, K ;
Tunstall-Pedoe, H ;
Underwood, R ;
Uretsky, BF ;
de Werf, FV ;
Voipio-Pulkki, LM ;
Wagner, G ;
Wallentin, L ;
Wijns, W .
EUROPEAN HEART JOURNAL, 2000, 21 (18) :1502-1513
[7]
Risk of arrhythmias in 52 755 long-distance cross-country skiers: a cohort study [J].
Andersen, Kasper ;
Farahmand, Bahman ;
Ahlbom, Anders ;
Held, Claes ;
Ljunghall, Sverker ;
Michaelsson, Karl ;
Sundstrom, Johan .
EUROPEAN HEART JOURNAL, 2013, 34 (47) :3624-3631
[8]
Analytical Characteristics of High-Sensitivity Cardiac Troponin Assays [J].
Apple, Fred S. ;
Collinson, Paul O. .
CLINICAL CHEMISTRY, 2012, 58 (01) :54-61
[9]
APPLE FS, 1984, CLIN CHEM, V30, P413
[10]
Aortic root size and prevalence of aortic regurgitation in elite strength trained athletes [J].
Babaee Bigi, Mohammad Ali ;
Aslani, Amir .
AMERICAN JOURNAL OF CARDIOLOGY, 2007, 100 (03) :528-530