Immunomodulating therapeutic approaches for multiple sclerosis

被引:5
作者
Karussis, DM [1 ]
Abramsky, O [1 ]
机构
[1] Hadassah Univ Hosp, Dept Neurol, IL-91120 Jerusalem, Israel
关键词
multiple sclerosis (MS); experimental autoimmune encephalomyelitis (EAE); immunomodulation;
D O I
10.1016/S0022-510X(97)00294-3
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
In this review we delineate the rationale for immunotherapy in multiple sclerosis and describe the various levels at which immune intervention, according to a modem model of the immune system organization, is feasible. Current and future immunosuppressive and immunomodulating therapeutic approaches at the level of antigen presentation and at the lymphocyte and cytokine network levels are discussed. (C) 1998 Elsevier Science B.V.
引用
收藏
页码:239 / 250
页数:12
相关论文
共 185 条
[1]   BOLUS METHYLPREDNISOLONE VERSUS ACTH IN THE TREATMENT OF MULTIPLE-SCLEROSIS [J].
ABBRUZZESE, G ;
GANDOLFO, C ;
LOEB, C .
ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES, 1983, 4 (02) :169-172
[2]   SUPPRESSION OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS BY INTERFERON [J].
ABREU, SL .
IMMUNOLOGICAL COMMUNICATIONS, 1982, 11 (01) :1-7
[3]   INTERFERON IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS (EAE) - EFFECTS OF EXOGENEOUS INTERFERON ON THE ANTIGEN-ENHANCED ADOPTIVE TRANSFER OF EAE [J].
ABREU, SL .
INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1985, 76 (04) :302-307
[4]   HOMEOSTASIS OF THE ANTIBODY-RESPONSE - IMMUNOREGULATION BY NK CELLS [J].
ABRUZZO, LV ;
ROWLEY, DA .
SCIENCE, 1983, 222 (4624) :581-585
[5]   OPEN CONTROLLED THERAPEUTIC TRIAL OF INTRAVENOUS IMMUNE GLOBULIN IN RELAPSING-REMITTING MULTIPLE-SCLEROSIS [J].
ACHIRON, A ;
PRAS, E ;
GILAD, R ;
ZIV, I ;
MANDEL, M ;
GORDON, CR ;
NOY, S ;
SAROVAPINHAS, I ;
MELAMED, E .
ARCHIVES OF NEUROLOGY, 1992, 49 (12) :1233-1236
[6]  
[Anonymous], 1991, Lancet, V337, P441
[7]   QUANTITATIVE MRI CHANGES IN GADOLINIUM-DTPA ENHANCEMENT AFTER HIGH-DOSE INTRAVENOUS METHYLPREDNISOLONE IN MULTIPLE-SCLEROSIS [J].
BARKHOF, F ;
HOMMES, OR ;
SCHELTENS, P ;
VALK, J .
NEUROLOGY, 1991, 41 (08) :1219-1222
[8]   INTRAVENOUS METHYLPREDNISOLONE FOR MULTIPLE-SCLEROSIS IN RELAPSE [J].
BARNES, MP ;
BATEMAN, DE ;
CLELAND, PG ;
DICK, DJ ;
WALLS, TJ ;
NEWMAN, PK ;
SAUNDERS, M ;
TILLEY, PJB .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1985, 48 (02) :157-159
[9]  
BAUMHEFNER RW, 1988, NEUROLOGY, V38, P69
[10]   THE EFFECT OF CORTICOSTEROIDS FOR ACUTE OPTIC NEURITIS ON THE SUBSEQUENT DEVELOPMENT OF MULTIPLE-SCLEROSIS [J].
BECK, RW ;
CLEARY, PA ;
TROBE, JD ;
KAUFMAN, DI ;
KUPERSMITH, MJ ;
PATY, DW ;
BROWN, CH .
NEW ENGLAND JOURNAL OF MEDICINE, 1993, 329 (24) :1764-1769