Adipocyte differentiation and gene expression

被引:580
作者
Ntambi, JM [1 ]
Kim, YC
机构
[1] Univ Wisconsin, Coll Agr & Life Sci, Dept Biochem, Madison, WI 53706 USA
[2] Univ Wisconsin, Coll Agr & Life Sci, Dept Nutr Sci, Madison, WI 53706 USA
关键词
adipose tissue; differentiation; preadipocytes; transcription factors;
D O I
10.1093/jn/130.12.3122S
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The major function of adipocytes is to store triacylglycerol in periods of energy excess and to mobilize this energy during times of deprivation. The short-term control of these lipogenic and lipolytic processes is carefully modulated by hormonal signals from the bloodstream, which provide an inventory of the body's metabolic state. Long-term changes in fat storage needs are accomplished by altering both the size and number of fat cells within the body because terminally differentiated adipocytes cannot divide. Alterations in the number of fat cells within the body must be accomplished by the differentiation of preadipocytes, which act as the renewable source of adipocytes. Our understanding of the events that occur during preadipocyte differentiation has advanced considerably in the last few years and has relied mainly on the use of tissue culture models of adipogenesis. This article will discuss the various models used for studying the preadipocyte differentiation process, with the mouse 3T3-L1 cell culture line described in detail. We focus on those genetic events that link effecters to induction of adipocyte gene expression.
引用
收藏
页码:3122S / 3126S
页数:5
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