Physiological and pathological roles of Apaf1 and the apoptosome

被引：46

作者：

Ferraro, E ^{[1
]}

Corvaro, M ^{[1
]}

Cecconi, F ^{[1
]}

机构：

[1] Univ Roma Tor Vergata, Dulbecco Telethon Inst, Dept Biol, I-00133 Rome, Italy

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2003年 / 7卷 / 01期

关键词：

apoptosis; cell death; neurodegeneration; Apaf1; apoptosome; caspases;

D O I：

10.1111/j.1582-4934.2003.tb00199.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Different cellular pathways can lead to apoptosis. Apaf1 is the molecular core of the apoptosome, a multiproteic complex mediating the so-called mitochondrial pathway of cell death. The importance of this pathway during development has been clearly demonstrated by knocking out key genes. Also, the relevance of Apaf I dosage during development has been recently underlined. Moreover, a growing body of evidences seems to point out a possible role of the mitochondria-dependent apoptosis in different pathologies. In particular, we discuss here some recent evidences regarding the putative role of the apoptosome in neurodegeneration and cancer.

引用

页码：21 / 34

页数：14

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