Axon guidance: GTPases help axons reach their targets

被引：68

作者：

Gallo, G ^{[1
]}

Letourneau, PC ^{[1
]}

机构：

[1] Univ Minnesota, Dept Cell Biol & Neuroanat, Minneapolis, MN 55455 USA

来源：

CURRENT BIOLOGY | 1998年 / 8卷 / 03期

关键词：

D O I：

10.1016/S0960-9822(98)70051-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During development and regeneration of the nervous system, axons must correctly navigate to their specific targets through a complex molecular environment. Recent work has shed light on how GTPases of the Ras family are involved in transducing extracellular signals into responses that lead to directed neurite outgrowth. (C) Current Biology Ltd.

引用

页码：R80 / R82

页数：3

共 8 条

[1] Jin Z, 1997, J NEUROSCI, V17, P6256
[2] Rho family GTPases and neuronal growth cone remodelling: Relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acid
Kozma, R
Sarner, S
Ahmed, S
Lim, L
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (03) : 1201 - 1211
[3] Lamoureux P, 1997, J CELL SCI, V110, P635
[4] Letourneau PC, 1996, PERSPECT DEV NEUROBI, V4, P111
[5] Rho family small GTP-binding proteins in growth cone signalling
Luo, LQ
Jan, LY
Jan, YN
[J]. CURRENT OPINION IN NEUROBIOLOGY, 1997, 7 (01) : 81 - 86
[6] Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton
Tapon, N
Hall, A
[J]. CURRENT OPINION IN CELL BIOLOGY, 1997, 9 (01) : 86 - 92
[7] Regulation of dendritic growth and remodeling by Rho, Rac, and Cdc42
Threadgill, R
Bobb, K
Ghosh, A
[J]. NEURON, 1997, 19 (03) : 625 - 634
[8] Role of a new Rho family member in cell migration and axon guidance in C-elegans
Zipkin, ID
Kindt, RM
Kenyon, CJ
[J]. CELL, 1997, 90 (05) : 883 - 894

← 1 →