The Relationship between Alternative Splicing and Proteomic Complexity

被引：141

作者：

Blencowe, Benjamin J. ^{[1
,2
]}

机构：

[1] Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada

[2] Univ Toronto, Dept Mol Genet, 160 Coll St, Toronto, ON M5S 3E1, Canada

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2017年 / 42卷 / 06期

关键词：

CONSEQUENCES;

D O I：

10.1016/j.tibs.2017.04.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

引用

收藏

页码：407 / 408

页数：2

相关论文

共 14 条

[1]

Alternatively Spliced Homologous Exons Have Ancient Origins and Are Highly Expressed at the Protein Level [J].

Abascal, Federico ;

Ezkurdia, Iakes ;

Rodriguez-Rivas, Juan ;

Manuel Rodriguez, Jose ;

del Pozo, Angela ;

Vazquez, Jesus ;

Valencia, Alfonso ;

Tress, Michael L. .

PLOS COMPUTATIONAL BIOLOGY, 2015, 11 (06)

[2]

Tissue-Specific Alternative Splicing Remodels Protein-Protein Interaction Networks [J].

Ellis, Jonathan D. ;

Barrios-Rodiles, Miriam ;

Colak, Recep ;

Irimia, Manuel ;

Kim, TaeHyung ;

Calarco, John A. ;

Wang, Xinchen ;

Pan, Qun ;

O'Hanlon, Dave ;

Kim, Philip M. ;

Wrana, Jeffrey L. ;

Blencowe, Benjamin J. .

MOLECULAR CELL, 2012, 46 (06) :884-892

[3]

Tunable protein synthesis by transcript isoforms in human cells [J].

Floor, Stephen N. ;

Doudna, Jennifer A. .

[4]

A Highly Conserved Program of Neuronal Microexons Is Misregulated in Autistic Brains [J].

Irimia, Manuel ;

Weatheritt, Robert J. ;

Ellis, Jonathan D. ;

Parikshak, Neelroop N. ;

Gonatopoulos-Pournatzis, Thomas ;

Babor, Mariana ;

Quesnel-Vallieres, Mathieu ;

Tapial, Javier ;

Raj, Bushra ;

O'Hanlon, Dave ;

Barrios-Rodiles, Miriam ;

Sternberg, Michael J. E. ;

Cordes, Sabine P. ;

Roth, Frederick P. ;

Wrana, Jeffrey L. ;

Geschwind, Daniel H. ;

Blencowe, Benjamin J. .

CELL, 2014, 159 (07) :1511-1523

[5]

Functional consequences of developmentally regulated alternative splicing [J].

Kalsotra, Auinash ;

Cooper, Thomas A. .

NATURE REVIEWS GENETICS, 2011, 12 (10) :715-729

[6]

On the Dependency of Cellular Protein Levels on mRNA Abundance [J].

Liu, Yansheng ;

Beyer, Andreas ;

Aebersold, Ruedi .

CELL, 2016, 165 (03) :535-550

[7]

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing [J].

Pan, Qun ;

Shai, Ofer ;

Lee, Leo J. ;

Frey, J. ;

Blencowe, Benjamin J. .

NATURE GENETICS, 2008, 40 (12) :1413-1415

[8]

Reproducible quantitative proteotype data matrices for systems biology [J].

Roest, Hannes L. ;

Malmstroem, Lars ;

Aebersold, Ruedi .

MOLECULAR BIOLOGY OF THE CELL, 2015, 26 (22) :3926-3931

[9]

Quantitative isoform-profiling of highly diversified recognition molecules [J].

Schreiner, Dietmar ;

Simicevic, Jovan ;

Ahrne, Erik ;

Schmidt, Alexander ;

Scheiffele, Peter .

[10]

Frac-seq reveals isoform-specific recruitment to polyribosomes [J].

Sterne-Weiler, Timothy ;

Martinez-Nunez, Rocio Teresa ;

Howard, Jonathan M. ;

Cvitovik, Ivan ;

Katzman, Sol ;

Tariq, Muhammad A. ;

Pourmand, Nader ;

Sanford, Jeremy R. .

GENOME RESEARCH, 2013, 23 (10) :1615-1623