A potent anti-diabetic agent from Kalopanax pictus

被引：65

作者：

Park, HJ ^{[1
]}

Kim, DH

Choi, JW

Park, JH

Han, YN

机构：

[1] Sangji Univ, Dept Bot Resources, Wonju 220702, South Korea

[2] Kyungsung Univ, Coll Pharm, Pusan 608736, South Korea

[3] Kyung Hee Univ, Coll Pharm, Seoul 130701, South Korea

[4] Pusan Natl Univ, Coll Pharm, Pusan 609735, South Korea

[5] Seoul Natl Univ, Inst Nat Prod Res, Seoul 110460, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 1998年 / 21卷 / 01期

关键词：

Kalopanax pictus; Araliaceae; anti-diabetic; kalopanaxsaponin A; hederagenin;

D O I：

10.1007/BF03216748

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

To search for the anti-diabetic principle from the stem bark of kalopanax pictus, seven kinds of chemical constituents including hederagenin glycosides and phenolic glycosides were isolated. The anti-diabetic evaluation of these isolates in the streptozotocin-induced diabetic rats exhibited that kalopanaxsaponin A has a potent anti-diabetic activity in contrast to a mild activity of hederagenin. In addition, significant hypocholesterolemic and hypolipidemic activities of kalopanaxsaponin A and hederagenin were observed. The structure-activity relationship of kalopanaxsaponin A was also investigated in the present work.

引用

页码：24 / 29

页数：6

共 17 条

[1]

CHO S-H, 1991, Archives of Pharmacal Research (Seoul), V14, P19, DOI 10.1007/BF02857808

[2]

EPSTEIN E, 1972, Annals of Clinical and Laboratory Science, V2, P244

[3]

HIGUCHI R, 1976, CHEM PHARM BULL, V24, P1021

[4]

Lee E., 1995, KOR J PHARMACOGN, V26, P122

[5]

Lee M. W., 1991, ARCH PHARM RES, V14, P124

[6]

MCGOWAN MW, 1983, CLIN CHEM, V29, P538

[7]

NOMA A, 1978, CLIN CHEM, V24, P1504

[8]

NORRA MD, 1985, PLANTA MED, V51, P43

[9]

PARK M-J, 1991, Archives of Pharmacal Research (Seoul), V14, P7, DOI 10.1007/BF02857806

[10] STUDIES ON THE CHEMICAL-CONSTITUENTS OF KALOPANAX-SEPTEMLOBUS [J].

PORZEL, A ;

SUNG, TV ;

SCHMIDT, J ;

LISCHEWSKI, M ;

ADAM, G .

PLANTA MEDICA, 1992, 58 (05) :481-482

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