Nicotine effects on skin: Are they positive or negative?

被引：68

作者：

Misery, L ^{[1
]}

机构：

[1] Univ Hosp, Dept Dermatol, Lab Cutaneous Neurobiol, F-29609 Brest, France

来源：

EXPERIMENTAL DERMATOLOGY | 2004年 / 13卷 / 11期

关键词：

fibroblast; inflammation; keratinocytes; nicotine; skin;

D O I：

10.1111/j.0906-6705.2004.00274.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The adverse effects of tobacco on the skin are well known but the role of nicotine is more controversial. Nicotinic receptors are expressed in the skin, on keratinocytes, fibroblasts and blood vessels. Nicotine induces vasoconstriction associated with local hyperaemia. It inhibits inflammation through effects on central and peripheral nervous system and through direct effect on immune cells. It delays wound healing and accelerates skin aging. The role of nicotine on skin diseases remains unclear. Therapeutic effects of nicotine could be possible and this a new stimulating field of research.

引用

页码：665 / 670

页数：6

共 69 条

[11] Induction of cyclooxygenase-2 mRNA and protein expression in human gingival fibroblasts stimulated with nicotine [J].

Chang, YC ;

Tsai, CH ;

Yang, SH ;

Liu, CM ;

Chou, MY .

JOURNAL OF PERIODONTAL RESEARCH, 2003, 38 (05) :496-501

[12] Neuronal nicotinic receptors in non-neuronal cells: new mediators of tobacco toxicity? [J].

Conti-Fine, BM ;

Navaneetham, D ;

Lei, S ;

Maus, ADJ .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2000, 393 (1-3) :279-294

[13] Acute nicotine poisoning associated with a traditional remedy for eczema [J].

Davies, P ;

Levy, S ;

Pahari, A ;

Martinez, D .

ARCHIVES OF DISEASE IN CHILDHOOD, 2001, 85 (06) :500-502

[14] Influx of calcium and chloride ions into epidermal keratinocytes regulates exocytosis of epidermal lamellar bodies and skin permeability barrier homeostasis [J].

Denda, M ;

Fuziwara, S ;

Inoue, K .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2003, 121 (02) :362-367

[15] Potentiation of evoked calcitonin gene-related peptide release from oral mucosa: a potential basis for the pro-inflammatory effects of nicotine [J].

Dussor, GO ;

Leong, AS ;

Gracia, NB ;

Kilo, S ;

Price, TJ ;

Hargreaves, KM ;

Flores, CM .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2003, 18 (09) :2515-2526

[16]

Eliakim R, 2003, ISRAEL MED ASSOC J, V5, P178

[17] KERATINOCYTE MUSCARINIC ACETYLCHOLINE-RECEPTORS - IMMUNOLOCALIZATION AND PARTIAL CHARACTERIZATION [J].

GRANDO, SA ;

ZELICKSON, BD ;

KIST, DA ;

WEINSHENKER, D ;

BIGLIARDI, PL ;

WENDELSCHAFERCRABB, G ;

KENNEDY, WR ;

DAHL, MV .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1995, 104 (01) :95-100

[18] A NICOTINIC ACETYLCHOLINE-RECEPTOR REGULATING CELL-ADHESION AND MOTILITY IS EXPRESSED IN HUMAN KERATINOCYTES [J].

GRANDO, SA ;

HORTON, RM ;

PEREIRA, EFR ;

DIETHELMOKITA, BM ;

GEORGE, PM ;

ALBUQUERQUE, EX ;

CONTIFINE, BM .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1995, 105 (06) :774-781

[19] Activation of keratinocyte nicotinic cholinergic receptors stimulates calcium influx and enhances cell differentiation [J].

Grando, SA ;

Horton, RM ;

Mauro, TM ;

Kist, DA ;

Lee, TX ;

Dahl, MV .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1996, 107 (03) :412-418

[20] HUMAN KERATINOCYTES SYNTHESIZE, SECRETE, AND DEGRADE ACETYLCHOLINE [J].

GRANDO, SA ;

KIST, DA ;

QI, M ;

DAHL, MV .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1993, 101 (01) :32-36

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