Noncoding RNAs and gene silencing

被引：342

作者：

Zaratiegui, Mikel ^{[1
]}

Irvine, Danielle V. ^{[1
]}

Martienssen, Robert A. ^{[1
]}

机构：

[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

来源：

CELL | 2007年 / 128卷 / 04期

关键词：

D O I：

10.1016/j.cell.2007.02.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Noncoding RNA has long been proposed to control gene expression via sequence-specific interactions with regulatory regions. Here, we review the role of noncoding RNA in heterochromatic silencing and in the silencing of transposable elements (TEs), unpaired DNA in meiosis, and developmentally excised DNA. The role of cotranscriptional processing by RNA interference and by other mechanisms is discussed, as well as parallels with RNA silencing in imprinting, paramutation, polycomb silencing, and X inactivation. Interactions with regulatory sequences may well occur, but at the RNA rather than at the DNA level. © 2007 Elsevier Inc. All rights reserved.

引用

页码：763 / 776

页数：14

共 130 条

[1] Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D-melanogaster germline [J].

Aravin, AA ;

Naumova, NM ;

Tulin, AV ;

Vagin, VV ;

Rozovsky, YM ;

Gvozdev, VA .

CURRENT BIOLOGY, 2001, 11 (13) :1017-1027

[2] Dissection of a natural RNA silencing process in the Drosophila melanogaster germ line [J].

Aravin, AA ;

Klenov, MS ;

Vagin, VV ;

Bantignies, F ;

Cavalli, G ;

Gvozdev, VA .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (15) :6742-6750

[3] A novel class of small RNAs bind to MILI protein in mouse testes [J].

Aravin, Alexei ;

Gaidatzis, Dimos ;

Pfeffer, Sebastien ;

Lagos-Quintana, Mariana ;

Landgraf, Pablo ;

Iovino, Nicola ;

Morris, Patricia ;

Brownstein, Michael J. ;

Kuramochi-Miyagawa, Satomi ;

Nakano, Toru ;

Chien, Minchen ;

Russo, James J. ;

Ju, Jingyue ;

Sheridan, Robert ;

Sander, Chris ;

Zavolan, Mihaela ;

Tuschl, Thomas .

NATURE, 2006, 442 (7099) :203-207

[4] Meiotic pairing and imprinted X chromatin assembly in Caenorhabditis elegans [J].

Bean, CJ ;

Schaner, CE ;

Kelly, WG .

NATURE GENETICS, 2004, 36 (01) :100-105

[5] Transposon silencing and imprint establishment in mammalian germ cells [J].

Bestor, TH ;

Bourc'his, D .

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 2004, 69 :381-387

[6] Accumulation of small murine minor satellite transcripts leads to impaired centromeric architecture and function [J].

Bouzinba-Segard, Haniaa ;

Guais, Adeline ;

Francastel, Claire .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (23) :8709-8714

[7] GENE REGULATION FOR HIGHER CELLS - A THEORY [J].

BRITTEN, RJ ;

DAVIDSON, EH .

SCIENCE, 1969, 165 (3891) :349-+

[8] Transcriptional silencing of nonsense codon-containing immunoglobulin minigenes [J].

Bühler, M ;

Mohn, F ;

Stalder, L ;

Mühlemann, O .

MOLECULAR CELL, 2005, 18 (03) :307-317

[9] Tethering RITS to a nascent transcript initiates RNAi- and heterochromatin-dependent gene silencing [J].

Buhler, Marc ;

Verdel, André ;

Moazed, Danesh .

CELL, 2006, 125 (05) :873-886

[10] Comprehensive analysis of heterochromatin- and RNAi-mediated epigenetic control of the fission yeast genome [J].

Cam, HP ;

Sugiyama, T ;

Chen, ES ;

Chen, X ;

FitzGerald, PC ;

Grewal, SIS .

NATURE GENETICS, 2005, 37 (08) :809-819

← 1 2 3 4 5 6 7 8 9 10 →