Effect of implant dose/volume and surgical resection on survival in a rat glioma brachytherapy model: Implications for brain tumor therapy

被引:6
作者
Bampoe, J
Glen, J
Mackenzie, I
Porter, P
Bernstein, M
机构
[1] UNIV TORONTO, TORONTO HOSP, TORONTO WESTERN DIV, DIV NEUROSURG, TORONTO, ON M5T 2S8, CANADA
[2] UNIV TORONTO, TORONTO HOSP, DIV NEUROPATHOL, TORONTO, ON M5T 2S8, CANADA
关键词
brachytherapy; rat brain tumor model; surgery; survival times;
D O I
10.1097/00006123-199712000-00026
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
OBJECTIVE: This study sought to investigate the effects of implant dose/volume and surgical resection on survival in a rat glioma brachytherapy model, Two doses were investigated to determine a suitable therapeutic range, METHODS: We performed two experiments. Three treatment groups and one control group of male F-344 rats bearing 9L brain tumors 12 days after tumor inoculation were used in the first experiment. Day 12 tumors were an average of 4 to 6 mm in diameter. Animals treated with brachytherapy received a tumor dose of 80 Gy delivered to a 5.5-mm-radius volume. Total macroscopic tumor removal was achieved by microsurgical techniques. A subsequent experiment compared the survival of tumor-burdened rats treated with an implant dose of 60 Gy delivered to a 5.5-mm-radius volume with a control group. RESULTS: Surgery alone produced an increased life span of 28.6% over control animals treated with sham surgery and dummy seed implants, a statistically significant increase in survival (P = 0.0023, log-rank test), Brachytherapy alone produced the most significant increase in survival over control animals (P = 0.0001, log-rank test; median survival not attained with an implant dose of 80 Gy delivered to a 5.5-mm-radius volume; and P = 0.0001, increased life span 121% with an implant dose of 60 Gy delivered to a 5.5-mm-radius volume). This was not improved by the addition of surgical tumor removal. CONCLUSION: We have demonstrated a relationship between implant dose/volume and survival of tumor-burdened rats in this model that is not improved by the addition of tumor removal. Implications for brain tumor brachytherapy are discussed.
引用
收藏
页码:1374 / 1383
页数:10
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