Bisbenzylisoquinoline alkaloids from Guatteria boliviana (Annonaceae)

被引：42

作者：

Mahiou, V ^{[1
]}

Roblot, F

Fournet, A

Hocquemiller, R

机构：

[1] Univ Mediterranee Aix Marseille 2, Fac Pharm, Lab Pharmacognosie, F-13385 Marseille 5, France

[2] Univ Paris 11, Fac Pharm, Lab Pharmacognosie, UPRES A 8076 CNRS BIOCIS, F-92296 Chatenay Malabry, France

[3] IRD, Dept Soc & Sante, F-78480 Paris 10, France

来源：

PHYTOCHEMISTRY | 2000年 / 54卷 / 07期

关键词：

Guatteria boliviana; annonaceae; bisbenzylisoquinoline; two-dimensional NMR; antiparasitic activity; cytotoxicity; Leishmania sp; Trypanosoma cruzi; Plasmodium falciparum;

D O I：

10.1016/S0031-9422(00)00178-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Together with known alkaloids, five new bisbenzylisoquinoline derivatives were isolated from the stem bark of Guatteria boliviana (Annonaceae), puertogalines-A 1 and -B 2, (+)-guatteboline 3, philogaline 4 and (-)-antioquine 5. Their structures were elucidated by spectrometric methods and their antiparasitic activity was evaluated in vitro on Leishmania sp., Trypanosoma cruzi and Plasmodium falciparum. Their cytotoxic activity was also measured in KB cell line. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：709 / 716

页数：8

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