Structure and function of the insulin-like growth factor I receptor

被引：94

作者：

Sepp-Lorenzino, L ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10021 USA

来源：

BREAST CANCER RESEARCH AND TREATMENT | 1998年 / 47卷 / 03期

关键词：

insulin-like growth factors (IGFs); IGF-I receptor; insulin receptor; regulation; signal transduction; structure;

D O I：

10.1023/A:1005955017615

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Insulin-like growth factors I and II (IGF-I, IGF-II) were originally identified as potent mitogens and as the mediators of growth hormone action. Besides being mitogenic, however, these polypeptide growth factors play a crucial role in cell survival, and contribute to transformation and to maintenance of the malignant phenotype. Here we will discuss signaling by the IGFs, focusing specifically on the structure and function of the IGF-I receptor and the domains of this receptor responsible for distinct IGF functions: mitogenesis, transformation, and protection from apoptosis. We will also compare the structural domains of the related but functionally distinct receptor for insulin.

引用

页码：235 / 253

页数：19

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