Pathogenic role of HMGB1 in SARS?

被引：42

作者：

Chen, GQ

Chen, DZ

Li, JH

Czura, CJ

Tracey, KJ

Sama, AE

Wang, HC ^{[1
]}

机构：

[1] NYU, N Shore Univ Hosp, Sch Med, Dept Emergency Med, Manhasset, NY 11030 USA

[2] N Shore LIJ Res Inst, Manhasset, NY 11030 USA

来源：

MEDICAL HYPOTHESES | 2004年 / 63卷 / 04期

关键词：

D O I：

10.1016/j.mehy.2004.01.037

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

High mobility group box 1 protein (HMGB1) is released by necrotic cells or activated macrophages/monocytes, and functions as a late mediator of Lethal systemic and Local pulmonary inflammation. Passive immunization with anti-HMGB1 antibodies confers significant protection against lethal endotoxemia, sepsis, and acute lung injury, even when antibodies are administered after the onset of these diseases. In tight of observations that three Chinese herbal formulations recommended for treatment of severe acute respiratory syndrome (SARS) specifically inhibited the release of HMGB1 from innate immune cells, we hypothesize that HMGB1 might occupy a pathogenic rote in SARS by mediating an injurious pulmonary inflammatory response. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：691 / 695

页数：5

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