Response of naive and memory CD8+ T cells to antigen stimulation in vivo

被引：433

作者：

Veiga-Fernandes, H ^{[1
]}

Walter, U

Bourgeois, C

McLean, A

Rocha, B

机构：

[1] Inst Necker, INSERM, U345, Paris, France

[2] Inst Necker, INSERM, U373, Paris, France

[3] Inst Anim Hlth, Compton, England

来源：

NATURE IMMUNOLOGY | 2000年 / 1卷 / 01期

关键词：

D O I：

10.1038/76907

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We studied the influence of memory T cell properties on the efficiency of secondary immune responses by comparing the in vivo immune response of the same numbers of T cell receptor (TCR) transgenic (Tg) naive and memory T cells. Compared to naive Tg cells, memory cells divided after a shorter lag time; had an increased division rate; a lower loss rate; and showed move rapid and efficient differentiation to effector functions. We found that initial naive T cell priming resulted in cells expressing mutually exclusive effector functions, whereas memory T cells were multifunctional after reactivation, with each individual cell expressing two to three different effector functions simultaneously. These special properties of memory T cells ensure the immediate control of reinfection.

引用

页码：47 / 53

页数：7

共 61 条

[1] Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation [J].