An effective aza-Michael addition of aromatic amines to electron-deficient alkenes in alkaline Al2O3

被引：46

作者：

Ai, Xin ^{[1
]}

Wang, Xin ^{[1
]}

Liu, Jin-ming ^{[1
]}

Ge, Ze-mei ^{[1
]}

Cheng, Tie-ming ^{[1
]}

Li, Run-tao ^{[1
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

来源：

TETRAHEDRON | 2010年 / 66卷 / 29期

关键词：

Aza-Michael addition; Aromatic amines; Aliphatic amines; Alkaline Al2O3; Solvent-free; LEWIS-ACID CATALYSIS; ALPHA; BETA-ETHYLENIC COMPOUNDS; ALIPHATIC-AMINES; EFFICIENT; SILICA; SOLVENT; ESTERS; WATER; HECK;

D O I：

10.1016/j.tet.2010.05.054

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aza-Michael addition of aromatic or aliphatic amines with various electron-deficient alkenes was performed using alkaline Al2O3 as solid media at room temperature afforded the corresponding Michael addition products in good to excellent yields. The alkaline Al2O3 can be easily recovered and reused. (C) 2010 Elsevier Ltd. All rights reserved.

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收藏

页码：5373 / 5377

页数：5

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