Serum prolactin levels are elevated also after pseudo-epileptic seizures

被引:34
作者
Alving, J [1 ]
机构
[1] Dianalund Epilepsy Hosp, Dept Clin Neurophysiol, DK-4293 Dianalund, Denmark
来源
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY | 1998年 / 7卷 / 02期
关键词
prolactin; epilepsy; pseudo-epileptic; differential diagnosis;
D O I
10.1016/S1059-1311(98)80046-0
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The aim of the study was to evaluate the sensitivity, specificity and the predictive values of repeated serum prolactin measurements in relation to epileptic seizures versus pseudoseizures. The method used was prospective measuring of serum prolactin from blood samples drawn (1) 15 min after seizure and (2) 2 hr after the first sample. Two parameters were used: the absolute maximal level; and the relative rise in blood level. In the study 38 had epilepsy (simple or complex partial seizures with or without secondary generalisation); and 20 had pseudo-epileptic seizures. In all cases, the diagnoses were made independent of the prolactin levels. In 30/38 (79%) of epilepsy patients and 17/20 (85%) of pseudoseizure patients, the diagnoses were corroborated by intensive EEG monitoring (video or cassette telemetry). There was a statistically significant rise in prolactin levels in both groups (p<0.0001 and <0.02, respectively), and also a significant difference between the two groups. However, repeated measurements in a number of patients (epilepsy: mean 1.5 measurements; pseudo; mean 2.1) showed also considerable intra-patient variations. The sensitivity for the maximal rise in pseudoseizures (5.5x) was only 20% and the negative predictive value 40%. For the cut-off in absolute level (1025 mu U/ml), the corresponding figures were 34% and 44%, respectively. The rather limited discriminative power of prolactin measurements makes it of questionable value in discerning between epileptic and pseudo-epileptic seizures.
引用
收藏
页码:85 / 89
页数:5
相关论文
共 19 条
[1]   SERUM PROLACTIN AND CORTISOL CONCENTRATIONS AFTER GRAND MAL SEIZURES [J].
ABBOTT, RJ ;
BROWNING, MCK ;
DAVIDSON, DLW .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1980, 43 (02) :163-167
[2]   SERUM PROLACTIN CONCENTRATIONS AND EPILEPSY - A STUDY WHICH COMPARES HEALTHY-SUBJECTS WITH A GROUP OF PATIENTS IN PRESURGICAL EVALUATION AND CIRCADIAN VARIATIONS WITH THOSE RELATED TO SEIZURES [J].
BAUER, J ;
STEFAN, H ;
SCHRELL, U ;
UHLIG, B ;
LANDGRAF, S ;
NEUBAUER, U ;
NEUNDORFER, B ;
BURR, W .
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 1992, 241 (06) :365-371
[3]   SERUM PROLACTIN RESPONSE TO REPETITIVE EPILEPTIC SEIZURES [J].
BAUER, J ;
KAUFMANN, P ;
KLINGMULLER, D ;
ELGER, CE .
JOURNAL OF NEUROLOGY, 1994, 241 (04) :242-245
[4]   SIMILAR POSTICTAL SERUM PROLACTIN RESPONSE IN COMPLEX PARTIAL SEIZURES OF TEMPORAL OR FRONTAL-LOBE ONSET [J].
BAUER, J ;
KAUFMANN, P ;
ELGER, CE ;
KLINGMULLER, D .
ARCHIVES OF NEUROLOGY, 1994, 51 (07) :645-645
[5]  
BOAS WV, 1987, ADV EPILEPTOL, V16, P147
[6]   PLASMA PROLACTIN CONCENTRATIONS FOLLOWING EPILEPTIC AND PSEUDOSEIZURES [J].
COLLINS, WCJ ;
LANIGAN, O ;
CALLAGHAN, N .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1983, 46 (06) :505-508
[7]   DIFFERENTIAL RESPONSE OF GROWTH-HORMONE, CORTISOL, AND PROLACTIN TO SEIZURES AND TO STRESS [J].
CULEBRAS, A ;
MILLER, M ;
BERTRAM, L ;
KOCH, J .
EPILEPSIA, 1987, 28 (05) :564-570
[8]   PROLACTIN AND GONADOTROPIN CHANGES FOLLOWING GENERALIZED AND PARTIAL SEIZURES [J].
DANAHAERI, J ;
TRIMBLE, MR ;
OXLEY, J .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1983, 46 (04) :331-335
[9]   Sensitivity and specificity of paired capillary prolactin measurement in diagnosis of seizures [J].
Ehsan, T ;
Fisher, RS ;
Johns, D ;
Lukas, RJ ;
Blum, D ;
Eskola, J .
JOURNAL OF EPILEPSY, 1996, 9 (02) :101-105
[10]   PROLACTIN CHANGES AFTER SEIZURES CLASSIFIED BY EEG MONITORING [J].
LAXER, KD ;
MULLOOLY, JP ;
HOWELL, B .
NEUROLOGY, 1985, 35 (01) :31-35