Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development

被引：367

作者：

Doulatov, Sergei ^{[1
,2
]}

Notta, Faiyaz ^{[1
,2
]}

Eppert, Kolja ^{[1
,2
]}

Nguyen, Linh T. ^{[3
,4
]}

Ohashi, Pamela S. ^{[3
,4
]}

Dick, John E. ^{[1
,2
]}

机构：

[1] Ontario Canc Inst, Campbell Family Canc Res Inst, Dept Stem Cell & Dev Biol, Univ Hlth Network, Toronto, ON M4X 1K9, Canada

[2] Univ Toronto, Dept Mol Genet, Toronto, ON, Canada

[3] Ontario Canc Inst, Campbell Family Canc Res Inst, Dept Med Biophys, Univ Hlth Network, Toronto, ON M4X 1K9, Canada

[4] Ontario Canc Inst, Campbell Family Canc Res Inst, Dept Immunol, Univ Hlth Network, Toronto, ON M4X 1K9, Canada

来源：

NATURE IMMUNOLOGY | 2010年 / 11卷 / 07期

关键词：

HUMAN CORD BLOOD; MULTIPOTENT HEMATOPOIETIC PROGENITORS; BONE-MARROW; LINEAGE COMMITMENT; STEM-CELLS; T-CELLS; B-CELLS; MYELOID PROGENITOR; THYMIC PROGENITORS; IDENTIFICATION;

D O I：

10.1038/ni.1889

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The classical model of hematopoiesis posits the segregation of lymphoid and myeloid lineages as the earliest fate decision. The validity of this model in the mouse has been questioned; however, little is known about the lineage potential of human progenitors. Here we provide a comprehensive analysis of the human hematopoietic hierarchy by clonally mapping the developmental potential of seven progenitor classes from neonatal cord blood and adult bone marrow. Human multilymphoid progenitors, identified as a distinct population of Thy-1(neg-lo)CD45RA(+) cells in the CD34(+)CD38(-) stem cell compartment, gave rise to all lymphoid cell types, as well as monocytes, macrophages and dendritic cells, which indicated that these myeloid lineages arise in early lymphoid lineage specification. Thus, as in the mouse, human hematopoiesis does not follow a rigid model of myeloid-lymphoid segregation.

引用

页码：585 / U52

页数：11

共 49 条

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