Rab27a:: a new face in β cell metabolism-secretion coupling

被引：26

作者：

Aizawa, T

Komatsu, M

机构：

[1] Shinshu Univ, Ctr Hlth Safety & Environm Management, Matsumoto, Nagano 3908621, Japan

[2] Shinshu Univ, Grad Sch Med, Dept Aging Med & Geriatr, Matsumoto, Nagano 3908621, Japan

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2005年 / 115卷 / 02期

关键词：

D O I：

10.1172/JCI200524269

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In pancreatic beta cells, not only insulin exocytosis per se, but translocation of beta granules toward the plasma membrane - an event upstream of exocytosis - are under the control of glucose. However, the molecular basis of this translocation has been poorly understood. Rab27a-mediated translocation of glucose-induced beta granules is reported in this issue of the JCI (see the related article beginning on page 388). Rab27a or its effector molecule may constitute a novel pharmacological target because potentiation of the Rab27a pathway is expected to restore beta cell glucose competency in patients with diabetes mellitus.

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页码：227 / 230

页数：4

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