Adult height and cryptogenic fibrosing alveolitis: a case-control study using the UK General Practice Research Database

被引:10
作者
Hubbard, R [1 ]
Venn, A [1 ]
机构
[1] Univ Nottingham, Div Resp Med, Nottingham NG7 2RD, England
关键词
cryptogenic fibrosing alveolitis; adult height; early life experience; UK General Practice Research Database;
D O I
10.1136/thorax.55.10.864
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Background-The reasons why cryptogenic fibrosing alveolitis has emerged as a new clinical entity during the second half of the 20th century are unclear. Some environmental exposures have been identified as potential risk factors including occupational dust, cigarette smoking and antidepressants, but there have been no studies of the role of early life exposures. Since adult height reflects, in part, early life experience, we have examined the relation between adult height and the risk of cryptogenic fibrosing alveolitis. Methods-A case-control study of 569 cases and 3669 age, sex, and community matched controls drawn from the UK General Practice Research Database was undertaken. Results-Evidence was found of an inverse association between quintile of height and cryptogenic fibrosing alveolitis (odds ratio (OR) per increase in height quintile 0.93, 95% CI 0.86 to 0.99). This association was not diminished by adjustment for smoking status (OR 0.93, 95% CI 0.87 to 1.00), but some minor attenuation did occur after adjustment for oral corticosteroid use (OR 0.94, 95% CI 0.88 to 1.02). There was a significant interaction with sex such that the effect of height was strong in women (OR 0.85, 95% CI 0.75 to 0.97) and absent in men (OR 1.00, 95% CI 0.91 to 1.09). Conclusions-These findings raise the possibility that early life exposures may be important in determining the lifetime risk of developing cryptogenic fibrosing alveolitis.
引用
收藏
页码:864 / 866
页数:3
相关论文
共 20 条
  • [1] Cigarette smoking: A risk factor for idiopathic pulmonary fibrosis
    Baumgartner, KB
    Samet, JM
    Stidley, CA
    Colby, TV
    Waldron, JA
    Coultas, DB
    Davis, GS
    Garcia, JGN
    Hunninghake, GW
    Kallay, MC
    King, TE
    Krowka, MJ
    Rennard, SI
    Ryu, JH
    Sherman, CB
    Smith, LJ
    Toews, G
    Winterbauer, RH
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1997, 155 (01) : 242 - 248
  • [2] BAUMGARTNER KB, 1997, AM J EPIDEMIOL, V45, pS61
  • [3] LUNG STRUCTURE AS A RISK FACTOR IN ADVERSE PULMONARY RESPONSES TO ASBESTOS EXPOSURE - A CASE-REFERENT STUDY IN QUEBEC CHRYSOTILE MINERS AND MILLERS
    BECKLAKE, MR
    TOYOTA, B
    STEWART, M
    HANSON, R
    HANLEY, J
    [J]. AMERICAN REVIEW OF RESPIRATORY DISEASE, 1983, 128 (03): : 385 - 388
  • [4] Exposure to commonly prescribed drugs and the etiology of cryptogenic fibrosing alveolitis - A case-control study
    Hubbard, R
    Venn, A
    Smith, C
    Cooper, M
    Johnston, I
    Britton, J
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1998, 157 (03) : 743 - 747
  • [5] Lung cancer and cryptogenic fibrosing alveolitis - A population-based cohort study
    Hubbard, R
    Venn, A
    Lewis, S
    Britton, J
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 161 (01) : 5 - 8
  • [6] Mortality rates from cryptogenic fibrosing alveolitis in seven countries
    Hubbard, R
    Johnston, I
    Coultas, DB
    Britton, J
    [J]. THORAX, 1996, 51 (07) : 711 - 716
  • [7] Occupational exposure to metal or wood dust and aetiology of cryptogenic fibrosing alveolitis
    Hubbard, R
    Lewis, S
    Richards, K
    Johnston, I
    Britton, J
    [J]. LANCET, 1996, 347 (8997) : 284 - 289
  • [8] IDIOPATHIC PULMONARY FIBROSIS - EPIDEMIOLOGIC APPROACHES TO OCCUPATIONAL EXPOSURE
    IWAI, K
    MORI, T
    YAMADA, N
    YAMAGUCHI, M
    HOSODA, Y
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1994, 150 (03) : 670 - 675
  • [9] The development of large and small airways
    Jeffery, PK
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1998, 157 (05) : S174 - S180
  • [10] THE EFFECTS OF MILD OBESITY ON LUNG-FUNCTION
    JENKINS, SC
    MOXHAM, J
    [J]. RESPIRATORY MEDICINE, 1991, 85 (04) : 309 - 311