Structural motifs of DNA complexes in the gas phase

被引:92
作者
Gidden, J [1 ]
Baker, ES [1 ]
Ferzoco, A [1 ]
Bowers, MT [1 ]
机构
[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA
关键词
ion mobility; DNA; helix; conformations;
D O I
10.1016/j.ijms.2004.09.011
中图分类号
O64 [物理化学(理论化学)、化学物理学]; O56 [分子物理学、原子物理学];
学科分类号
070203 ; 070304 ; 081704 ; 1406 ;
摘要
DNA duplexes are known to be quite stable in the condensed phase but recent mass spectrometry results have shown that DNA complexes are also stable (at least for a limited time) in the gas phase. However, very little is known about the overall shape of the complexes in a solvent-free. environment and what factors influence that shape. In this article, we present recent ion mobility and molecular modeling results that address some issues concerning the gas-phase conformations of DNA duplexes. Examples include the effect of metal ions on Watson-Crick base, pairing, investigating the onset of helicity in duplexes as a function of strand length. comparison of the stability of C(.)G and A(.)T base pairs, and examining the formation of quadruplex structures. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码:183 / 193
页数:11
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