Lymphotoxin-mediated regulation of γδ cell differentiation by αβ T cell progenitors

被引：125

作者：

Silva-Santos, B ^{[1
]}

Pennington, DJ ^{[1
]}

Hayday, AC ^{[1
]}

机构：

[1] Univ London Kings Coll, Guys Hosp, Guys Kings St Thomas Med Sch, Peter Gorer Dept Immunobiol, London SE1 9RT, England

来源：

SCIENCE | 2005年 / 307卷 / 5711期

基金：

英国惠康基金;

关键词：

D O I：

10.1126/science.1103978

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The thymus gives rise to two T cell lineages, alphabeta and gammadelta, that are thought to develop independently of one another. Hence, double positive (DP) thymocytes expressing CD4 and CD8 coreceptors are usually viewed simply as progenitors of CD4(+) and CD8(+) alphabeta T cells. Instead we report that DIP cells regulate the differentiation of early thymocyte progenitors and gammadelta cells, by a mechanism dependent on the transcription factor RORgammat, and the lymphotoxin (Lt) beta receptor (LTbetaR). This finding provokes a revised view of the thymus, in which lymphoid-tissue induction-type processes coordinate the developmental and functional integration of the two T cell lineages.

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页码：925 / 928

页数：4

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