The role of lipoprotein lipase in adipose tissue development and metabolism

被引：55

作者：

Zechner, R

Strauss, J

Frank, S

Wagner, E

Hofmann, W

Kratky, D

Hiden, M

Levak-Frank, S

机构：

[1] Graz Univ, Inst Mol Biol Biochem & Microbiol, A-8010 Graz, Austria

[2] Graz Univ, Inst Med Biochem & Med Mol Biol, A-8010 Graz, Austria

来源：

INTERNATIONAL JOURNAL OF OBESITY | 2000年 / 24卷 / Suppl 4期

基金：

奥地利科学基金会;

关键词：

lipoprotein lipase; adipose tissue; muscle; transgenic mouse;

D O I：

10.1038/sj.ijo.0801506

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Lipoprotein lipase (LPL) is essential for the hydrolysis and distribution of triglyceride-rich lipoprotein-associated fatty acids among extrahepatic tissues. Additionally, the enzyme facilitates several non-lipolysis associated functions including the cellular uptake of whole lipoprotein particles and lipophilic vitamins. The tissue-specific variations of LPL expression have been implicated in the pathogenesis of various lipid disorders, obesity and atherosclerosis. Transgenic technology provided the means to study the physiological response to the overexpression or absence of the enzyme in adipose tissue, muscle and macrophages. The effects of varying LPL expression in adipose tissue and muscle are summarized in this article.

引用

收藏

页码：S53 / S56

页数：4

相关论文

共 21 条

[1] Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in vivo [J].

Babaev, VR ;

Fazio, S ;

Gleaves, LA ;

Carter, KJ ;

Semenkovich, CF ;

Linton, MF .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (12) :1697-1705

[2] Premature atherosclerosis in patients with familial chylomicronemia caused by mutations in the lipoprotein lipase gene [J].

Benlian, P ;

DeGennes, JL ;

Foubert, L ;

Zhang, HF ;

Gagne, SE ;

Hayden, M .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (12) :848-854

[3] FAMILIAL LIPOPROTEIN-LIPASE ACTIVITY DEFICIENCY - STUDY OF TOTAL-BODY FATNESS AND SUBCUTANEOUS FAT TISSUE DISTRIBUTION [J].

BRUN, LD ;

GAGNE, C ;

JULIEN, P ;

TREMBLAY, A ;

MOORJANI, S ;

BOUCHARD, C ;

LUPIEN, PJ .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1989, 38 (10) :1005-1009

[4]

Brunzell JD, 1995, METABOLIC MOL BASES, P1913

[5] COOH-TERMINAL DISRUPTION OF LIPOPROTEIN-LIPASE IN MICE IS LETHAL IN HOMOZYGOTES, BUT HETEROZYGOTES HAVE ELEVATED TRIGLYCERIDES AND IMPAIRED ENZYME-ACTIVITY [J].

COLEMAN, T ;

SEIP, RL ;

GIMBLE, JM ;

LEE, D ;

MAEDA, N ;

SEMENKOVICH, CF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (21) :12518-12525

[6]

GREENWOOD MRC, 1981, RECENT ADV OBESITY R, V3, P75

[7] Cloning of a unique lipase from endothelial cells extends the lipase gene family [J].

Hirata, K ;

Dichek, HL ;

Cioffi, JA ;

Choi, SY ;

Leeper, NJ ;

Quintana, L ;

Kronmal, GS ;

Cooper, AD ;

Quertermous, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (20) :14170-14175

[8] A novel endothelial-derived lipase that modulates HDL metabolism [J].

Jaye, M ;

Lynch, KJ ;

Krawiec, T ;

Marchadier, D ;

Maugeais, C ;

Doan, K ;

South, V ;

Amin, D ;

Perrone, M ;

Rader, DJ .

NATURE GENETICS, 1999, 21 (04) :424-428

[9] Prevention of diet-induced obesity in transgenic mice overexpressing skeletal muscle lipoprotein lipase [J].

Jensen, DR ;

Schlaepfer, IR ;

Morin, CL ;

Pennington, DS ;

Marcell, T ;

Ammon, SM ;

GutierrezHartmann, A ;

Eckel, RH .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1997, 273 (02) :R683-R689

[10] Induced mutant mouse lines that express lipoprotein lipase in cardiac muscle, but not in skeletal muscle and adipose tissue, have normal plasma triglyceride and high-density lipoprotein-cholesterol levels [J].

Levak-Frank, S ;

Hofmann, W ;

Weinstock, PH ;

Radner, H ;

Sattler, W ;

Breslow, JL ;

Zechner, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (06) :3165-3170