Dystrophin-deficient muscular dystrophy in a weimaraner

被引:23
作者
Baltzer, Wendy Irene
Calise, David V.
Leving, Jonathan M.
Shelton, G. D.
Edwards, John F.
Steiner, Joerg M.
机构
[1] Oregon State Univ, Coll Vet Med, Dept Clin Sci, Corvallis, OR 97331 USA
[2] Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Pathobiol, College Stn, TX 77843 USA
[3] Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Small Anim Med & Surg, College Stn, TX 77843 USA
[4] Univ Calif San Diego, Sch Med, Dept Pathol, La Jolla, CA 92093 USA
关键词
D O I
10.5326/0430227
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
A 2-year old male Weimaraner with muscular dystrophy was presented with generalized muscle atrophy of the limbs hypertrophy of the neck infraspinatus and lingual muscles dysphagia and regurgitation Unilateral cryptorchidism unilateral renal agenesis and hiatal hernia were also detected Spontaneous muscle activity was identified on myography Serum creatine kinase was markedly elevated Immunohistochemical staining for dystrophin was restricted to suspected revertant (characteristics of immaturity) fibers. Histologically skeletal myofiber degeneration endomysial fibrosis and mineralization were present Following euthanasia necropsy revealed hypertrophy of the diaphragm and cardiac muscle fibrosis This case of muscular dystrophy represents a slowly progressive form with organ agenesis.
引用
收藏
页码:227 / 232
页数:6
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