共 10 条
ABC Transporters in Drug-Refractory Epilepsy: Limited Clinical Significance of Pharmacogenetics?
被引:27
作者:

Cascorbi, I.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Schleswig Holstein, Inst Expt & Clin Pharmacol, Kiel, Germany Univ Hosp Schleswig Holstein, Inst Expt & Clin Pharmacol, Kiel, Germany
机构:
[1] Univ Hosp Schleswig Holstein, Inst Expt & Clin Pharmacol, Kiel, Germany
关键词:
MULTIDRUG-RESISTANCE;
P-GLYCOPROTEIN;
POLYMORPHISM;
EXPRESSION;
GENE;
ASSOCIATION;
D O I:
10.1038/clpt.2009.237
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
引用
收藏
页码:15 / 18
页数:4
相关论文
共 10 条
[1]
Differences in the transport of the antiepileptic drugs phenytoin, levetiracetarn and carbamazepine by human and mouse P-glycoprotein
[J].
Baltes, Steffen
;
Gastens, Alexandra M.
;
Fedrowitz, Maren
;
Potschka, Heidrun
;
Kaever, Volkhard
;
Loescher, Wolfgang
.
NEUROPHARMACOLOGY,
2007, 52 (02)
:333-346

Baltes, Steffen
论文数: 0 引用数: 0
h-index: 0
机构: Univ Vet Med Hannover, Dept Pharmacol Toxicol & Pharm, D-30559 Hannover, Germany

Gastens, Alexandra M.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Vet Med Hannover, Dept Pharmacol Toxicol & Pharm, D-30559 Hannover, Germany

Fedrowitz, Maren
论文数: 0 引用数: 0
h-index: 0
机构: Univ Vet Med Hannover, Dept Pharmacol Toxicol & Pharm, D-30559 Hannover, Germany

Potschka, Heidrun
论文数: 0 引用数: 0
h-index: 0
机构: Univ Vet Med Hannover, Dept Pharmacol Toxicol & Pharm, D-30559 Hannover, Germany

Kaever, Volkhard
论文数: 0 引用数: 0
h-index: 0
机构: Univ Vet Med Hannover, Dept Pharmacol Toxicol & Pharm, D-30559 Hannover, Germany

Loescher, Wolfgang
论文数: 0 引用数: 0
h-index: 0
机构: Univ Vet Med Hannover, Dept Pharmacol Toxicol & Pharm, D-30559 Hannover, Germany
[2]
Polymorphism of the MDR1/ABCB1 C3435T drug-transporter and resistance to anticonvulsant drugs: A meta-analysis
[J].
Bournissen, Facundo Garcia
;
Moretti, Myla E.
;
Juurlink, David N.
;
Koren, Gideon
;
Walker, Mugabe
;
Finkelstein, Yaron
.
EPILEPSIA,
2009, 50 (04)
:898-903

Bournissen, Facundo Garcia
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Toronto, Hosp Sick Children, Dept Pediat, Div Clin Pharmacol & Toxicol, Toronto, ON M5G 1X8, Canada Univ Toronto, Hosp Sick Children, Dept Pediat, Div Clin Pharmacol & Toxicol, Toronto, ON M5G 1X8, Canada

Moretti, Myla E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Toronto, Hosp Sick Children, Dept Pediat, Div Clin Pharmacol & Toxicol, Toronto, ON M5G 1X8, Canada Univ Toronto, Hosp Sick Children, Dept Pediat, Div Clin Pharmacol & Toxicol, Toronto, ON M5G 1X8, Canada

Juurlink, David N.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Toronto, Hosp Sick Children, Dept Pediat, Div Clin Pharmacol & Toxicol, Toronto, ON M5G 1X8, Canada Univ Toronto, Hosp Sick Children, Dept Pediat, Div Clin Pharmacol & Toxicol, Toronto, ON M5G 1X8, Canada

Koren, Gideon
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Toronto, Hosp Sick Children, Dept Pediat, Div Clin Pharmacol & Toxicol, Toronto, ON M5G 1X8, Canada Univ Toronto, Hosp Sick Children, Dept Pediat, Div Clin Pharmacol & Toxicol, Toronto, ON M5G 1X8, Canada

Walker, Mugabe
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Toronto, Hosp Sick Children, Dept Pediat, Div Emergency Med, Toronto, ON M5G 1X8, Canada Univ Toronto, Hosp Sick Children, Dept Pediat, Div Clin Pharmacol & Toxicol, Toronto, ON M5G 1X8, Canada

Finkelstein, Yaron
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Toronto, Hosp Sick Children, Dept Pediat, Div Clin Pharmacol & Toxicol, Toronto, ON M5G 1X8, Canada
Univ Toronto, Hosp Sick Children, Dept Pediat, Div Emergency Med, Toronto, ON M5G 1X8, Canada Univ Toronto, Hosp Sick Children, Dept Pediat, Div Clin Pharmacol & Toxicol, Toronto, ON M5G 1X8, Canada
[3]
Role of pharmacogenetics of ATP-binding cassette transporters in the pharmacokinetics of drugs
[J].
Cascorbi, Ingolf
.
PHARMACOLOGY & THERAPEUTICS,
2006, 112 (02)
:457-473

Cascorbi, Ingolf
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Kiel, Hosp Schleswig Holstein, Inst Pharmacol, D-24105 Kiel, Germany Univ Kiel, Hosp Schleswig Holstein, Inst Pharmacol, D-24105 Kiel, Germany
[4]
Functional polymorphisms of the human multidrug-resistance gene:: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
[J].
Hoffmeyer, S
;
Burk, O
;
von Richter, O
;
Arnold, HP
;
Brockmöller, J
;
Johne, A
;
Cascorbi, I
;
Gerloff, T
;
Roots, I
;
Eichelbaum, M
;
Brinkmann, U
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2000, 97 (07)
:3473-3478

Hoffmeyer, S
论文数: 0 引用数: 0
h-index: 0
机构: Pharmacogenet Lab, Epidauros Biotechnol, D-82347 Bernried, Germany

Burk, O
论文数: 0 引用数: 0
h-index: 0
机构: Pharmacogenet Lab, Epidauros Biotechnol, D-82347 Bernried, Germany

von Richter, O
论文数: 0 引用数: 0
h-index: 0
机构: Pharmacogenet Lab, Epidauros Biotechnol, D-82347 Bernried, Germany

Arnold, HP
论文数: 0 引用数: 0
h-index: 0
机构: Pharmacogenet Lab, Epidauros Biotechnol, D-82347 Bernried, Germany

Brockmöller, J
论文数: 0 引用数: 0
h-index: 0
机构: Pharmacogenet Lab, Epidauros Biotechnol, D-82347 Bernried, Germany

Johne, A
论文数: 0 引用数: 0
h-index: 0
机构: Pharmacogenet Lab, Epidauros Biotechnol, D-82347 Bernried, Germany

Cascorbi, I
论文数: 0 引用数: 0
h-index: 0
机构: Pharmacogenet Lab, Epidauros Biotechnol, D-82347 Bernried, Germany

Gerloff, T
论文数: 0 引用数: 0
h-index: 0
机构: Pharmacogenet Lab, Epidauros Biotechnol, D-82347 Bernried, Germany

Roots, I
论文数: 0 引用数: 0
h-index: 0
机构: Pharmacogenet Lab, Epidauros Biotechnol, D-82347 Bernried, Germany

Eichelbaum, M
论文数: 0 引用数: 0
h-index: 0
机构: Pharmacogenet Lab, Epidauros Biotechnol, D-82347 Bernried, Germany

Brinkmann, U
论文数: 0 引用数: 0
h-index: 0
机构: Pharmacogenet Lab, Epidauros Biotechnol, D-82347 Bernried, Germany
[5]
One of the hottest topics in epileptology: ABC proteins. Their inhibition may be the future for patients with intractable seizures
[J].
Hughes, John R.
.
NEUROLOGICAL RESEARCH,
2008, 30 (09)
:920-925

Hughes, John R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Illinois, Med Ctr, Dept Neurol, Chicago, IL 60612 USA Univ Illinois, Med Ctr, Dept Neurol, Chicago, IL 60612 USA
[6]
The clinical impact of pharmacogenetics on the treatment of epilepsy
[J].
Loescher, Wolfgang
;
Klotz, Ulrich
;
Zimprich, Fritz
;
Schmidt, Dieter
.
EPILEPSIA,
2009, 50 (01)
:1-23

Loescher, Wolfgang
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Vet Med Hannover, Dept Pharmacol Toxicol & Pharm, Hannover, Germany Univ Vet Med Hannover, Dept Pharmacol Toxicol & Pharm, Hannover, Germany

Klotz, Ulrich
论文数: 0 引用数: 0
h-index: 0
机构:
Dr Margarete Fischer Bosch Inst Clin Pharmacol, D-7000 Stuttgart, Germany
Univ Tubingen, Stuttgart, Germany Univ Vet Med Hannover, Dept Pharmacol Toxicol & Pharm, Hannover, Germany

Zimprich, Fritz
论文数: 0 引用数: 0
h-index: 0
机构:
Med Univ Vienna, Dept Clin Neurol, Vienna, Austria Univ Vet Med Hannover, Dept Pharmacol Toxicol & Pharm, Hannover, Germany

Schmidt, Dieter
论文数: 0 引用数: 0
h-index: 0
机构:
Epilepsy Res Grp, Berlin, Germany Univ Vet Med Hannover, Dept Pharmacol Toxicol & Pharm, Hannover, Germany
[7]
Association of ABCB1 genetic variants 3435C>T and 2677G>T to ABCB1 mRNA and protein expression
[J].
Mosyagin, Igor
;
Runge, Uwe
;
Schroeder, Henry W.
;
Dazert, Eike
;
Vogelgesang, Silke
;
Siegmund, Werner
;
Warzok, Rolf W.
;
Cascorbi, Ingolf
.
EPILEPSIA,
2008, 49 (09)
:1555-1561

Mosyagin, Igor
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Schleswig Holstein, Inst Pharmacol, D-24105 Kiel, Germany Univ Hosp Schleswig Holstein, Inst Pharmacol, D-24105 Kiel, Germany

Runge, Uwe
论文数: 0 引用数: 0
h-index: 0
机构:
Ernst Moritz Arndt Univ Greifswald, Dept Neurol, Greifswald, Germany Univ Hosp Schleswig Holstein, Inst Pharmacol, D-24105 Kiel, Germany

Schroeder, Henry W.
论文数: 0 引用数: 0
h-index: 0
机构:
Ernst Moritz Arndt Univ Greifswald, Dept Neurosurg, Greifswald, Germany Univ Hosp Schleswig Holstein, Inst Pharmacol, D-24105 Kiel, Germany

Dazert, Eike
论文数: 0 引用数: 0
h-index: 0
机构:
Ernst Moritz Arndt Univ Greifswald, Dept Neuropathol, Greifswald, Germany Univ Hosp Schleswig Holstein, Inst Pharmacol, D-24105 Kiel, Germany

Vogelgesang, Silke
论文数: 0 引用数: 0
h-index: 0
机构:
Ernst Moritz Arndt Univ Greifswald, Dept Neuropathol, Greifswald, Germany Univ Hosp Schleswig Holstein, Inst Pharmacol, D-24105 Kiel, Germany

Siegmund, Werner
论文数: 0 引用数: 0
h-index: 0
机构:
Ernst Moritz Arndt Univ Greifswald, Dept Clin Pharmacol, Greifswald, Germany Univ Hosp Schleswig Holstein, Inst Pharmacol, D-24105 Kiel, Germany

Warzok, Rolf W.
论文数: 0 引用数: 0
h-index: 0
机构:
Ernst Moritz Arndt Univ Greifswald, Dept Neuropathol, Greifswald, Germany Univ Hosp Schleswig Holstein, Inst Pharmacol, D-24105 Kiel, Germany

Cascorbi, Ingolf
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Schleswig Holstein, Inst Pharmacol, D-24105 Kiel, Germany Univ Hosp Schleswig Holstein, Inst Pharmacol, D-24105 Kiel, Germany
[8]
Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1
[J].
Siddiqui, A
;
Kerb, R
;
Weale, ME
;
Brinkmann, U
;
Smith, A
;
Goldstein, DB
;
Wood, NW
;
Sisodiya, SM
.
NEW ENGLAND JOURNAL OF MEDICINE,
2003, 348 (15)
:1442-1448

Siddiqui, A
论文数: 0 引用数: 0
h-index: 0
机构: UCL, Inst Neurol, Dept Clin & Expt Epilepsy, London WC1N 3BG, England

Kerb, R
论文数: 0 引用数: 0
h-index: 0
机构: UCL, Inst Neurol, Dept Clin & Expt Epilepsy, London WC1N 3BG, England

Weale, ME
论文数: 0 引用数: 0
h-index: 0
机构: UCL, Inst Neurol, Dept Clin & Expt Epilepsy, London WC1N 3BG, England

Brinkmann, U
论文数: 0 引用数: 0
h-index: 0
机构: UCL, Inst Neurol, Dept Clin & Expt Epilepsy, London WC1N 3BG, England

Smith, A
论文数: 0 引用数: 0
h-index: 0
机构: UCL, Inst Neurol, Dept Clin & Expt Epilepsy, London WC1N 3BG, England

Goldstein, DB
论文数: 0 引用数: 0
h-index: 0
机构: UCL, Inst Neurol, Dept Clin & Expt Epilepsy, London WC1N 3BG, England

Wood, NW
论文数: 0 引用数: 0
h-index: 0
机构: UCL, Inst Neurol, Dept Clin & Expt Epilepsy, London WC1N 3BG, England

Sisodiya, SM
论文数: 0 引用数: 0
h-index: 0
机构:
UCL, Inst Neurol, Dept Clin & Expt Epilepsy, London WC1N 3BG, England UCL, Inst Neurol, Dept Clin & Expt Epilepsy, London WC1N 3BG, England
[9]
MDR1 GENE-EXPRESSION IN BRAIN OF PATIENTS WITH MEDICALLY INTRACTABLE EPILEPSY
[J].
TISHLER, DM
;
WEINBERG, KI
;
HINTON, DR
;
BARBARO, N
;
ANNETT, GM
;
RAFFEL, C
.
EPILEPSIA,
1995, 36 (01)
:1-6

TISHLER, DM
论文数: 0 引用数: 0
h-index: 0
机构: CHILDRENS HOSP LOS ANGELES,DIV HEMATOL ONCOL,LOS ANGELES,CA 90027

WEINBERG, KI
论文数: 0 引用数: 0
h-index: 0
机构: CHILDRENS HOSP LOS ANGELES,DIV HEMATOL ONCOL,LOS ANGELES,CA 90027

HINTON, DR
论文数: 0 引用数: 0
h-index: 0
机构: CHILDRENS HOSP LOS ANGELES,DIV HEMATOL ONCOL,LOS ANGELES,CA 90027

BARBARO, N
论文数: 0 引用数: 0
h-index: 0
机构: CHILDRENS HOSP LOS ANGELES,DIV HEMATOL ONCOL,LOS ANGELES,CA 90027

ANNETT, GM
论文数: 0 引用数: 0
h-index: 0
机构: CHILDRENS HOSP LOS ANGELES,DIV HEMATOL ONCOL,LOS ANGELES,CA 90027

RAFFEL, C
论文数: 0 引用数: 0
h-index: 0
机构: CHILDRENS HOSP LOS ANGELES,DIV HEMATOL ONCOL,LOS ANGELES,CA 90027
[10]
Non-response to antiepileptic pharmacotherapy is associated with the ABCC2-24C>T polymorphism in young and adult patients with epilepsy
[J].
Ufer, Mike
;
Mosyagin, Igor
;
Muhle, Hiltrud
;
Jacobsen, Thies
;
Haenisch, Sierk
;
Haesler, Robert
;
Faltraco, Frank
;
Remmler, Cornelia
;
von Spiczak, Sarah
;
Kroemer, Heyo K.
;
Runge, Uwe
;
Boor, Rainer
;
Stephani, Ulrich
;
Cascorbi, Ingolf
.
PHARMACOGENETICS AND GENOMICS,
2009, 19 (05)
:353-362

Ufer, Mike
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Schleswig Holstein, Inst Expt & Clin Pharmacol, D-24105 Kiel, Germany Univ Hosp Schleswig Holstein, Inst Expt & Clin Pharmacol, D-24105 Kiel, Germany

Mosyagin, Igor
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Schleswig Holstein, Inst Expt & Clin Pharmacol, D-24105 Kiel, Germany Univ Hosp Schleswig Holstein, Inst Expt & Clin Pharmacol, D-24105 Kiel, Germany

Muhle, Hiltrud
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Schleswig Holstein, Dept Neuropediat, D-24105 Kiel, Germany Univ Hosp Schleswig Holstein, Inst Expt & Clin Pharmacol, D-24105 Kiel, Germany

Jacobsen, Thies
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Schleswig Holstein, Inst Expt & Clin Pharmacol, D-24105 Kiel, Germany Univ Hosp Schleswig Holstein, Inst Expt & Clin Pharmacol, D-24105 Kiel, Germany

Haenisch, Sierk
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Schleswig Holstein, Inst Expt & Clin Pharmacol, D-24105 Kiel, Germany Univ Hosp Schleswig Holstein, Inst Expt & Clin Pharmacol, D-24105 Kiel, Germany

Haesler, Robert
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Kiel, Inst Clin Mol Biol, Kiel, Germany Univ Hosp Schleswig Holstein, Inst Expt & Clin Pharmacol, D-24105 Kiel, Germany

Faltraco, Frank
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Schleswig Holstein, Inst Expt & Clin Pharmacol, D-24105 Kiel, Germany Univ Hosp Schleswig Holstein, Inst Expt & Clin Pharmacol, D-24105 Kiel, Germany

Remmler, Cornelia
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Schleswig Holstein, Inst Expt & Clin Pharmacol, D-24105 Kiel, Germany Univ Hosp Schleswig Holstein, Inst Expt & Clin Pharmacol, D-24105 Kiel, Germany

von Spiczak, Sarah
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Schleswig Holstein, Dept Neuropediat, D-24105 Kiel, Germany Univ Hosp Schleswig Holstein, Inst Expt & Clin Pharmacol, D-24105 Kiel, Germany

Kroemer, Heyo K.
论文数: 0 引用数: 0
h-index: 0
机构:
Ernst Moritz Arndt Univ Greifswald, Dept Pharmacol, Greifswald, Germany Univ Hosp Schleswig Holstein, Inst Expt & Clin Pharmacol, D-24105 Kiel, Germany

Runge, Uwe
论文数: 0 引用数: 0
h-index: 0
机构:
Ernst Moritz Arndt Univ Greifswald, Dept Neurol, Greifswald, Germany Univ Hosp Schleswig Holstein, Inst Expt & Clin Pharmacol, D-24105 Kiel, Germany

Boor, Rainer
论文数: 0 引用数: 0
h-index: 0
机构:
No German Epilepsy Ctr, Raisdorf, Germany Univ Hosp Schleswig Holstein, Inst Expt & Clin Pharmacol, D-24105 Kiel, Germany

Stephani, Ulrich
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Schleswig Holstein, Dept Neuropediat, D-24105 Kiel, Germany
No German Epilepsy Ctr, Raisdorf, Germany Univ Hosp Schleswig Holstein, Inst Expt & Clin Pharmacol, D-24105 Kiel, Germany

Cascorbi, Ingolf
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Schleswig Holstein, Inst Expt & Clin Pharmacol, D-24105 Kiel, Germany Univ Hosp Schleswig Holstein, Inst Expt & Clin Pharmacol, D-24105 Kiel, Germany