A concise route to the core pentasaccharide of N-linked glycoproteins

被引：38

作者：

Dudkin, VY

Miller, JS

Danishefsky, SJ

机构：

[1] Sloan Kettering Inst Canc Res, Bioorgan Chem Lab, New York, NY 10021 USA

[2] Columbia Univ, Dept Chem, New York, NY 10027 USA

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(03)00101-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise preparation of the common pentasaccharide core of the N-linked glycoproteins is described. The reducing end glycal is functionalized at the level of chitobiose, which is then beta-mannosylated using Crich's direct coupling protocol. Deprotection of the branching mannose residue, and di-alpha-mannosylation complete the synthesis. (C) 2003 Elsevier Science Ltd. All rights reserved.

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页码：1791 / 1793

页数：3

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