Inflammasomes as microbial sensors

被引:103
作者
Franchi, Luigi
Munoz-Planillo, Raul
Reimer, Thornik
Eigenbrod, Tatjana
Nunez, Gabriel [1 ]
机构
[1] Univ Michigan, Dept Pathol, Sch Med, Ann Arbor, MI 48109 USA
基金
瑞士国家科学基金会;
关键词
Caspase-1; Inflammasome IL-1 beta; Nlrc4; Nlrp3; CASPASE-1; ACTIVATION; NLRP3; INFLAMMASOME; NALP3; PATTERN-RECOGNITION; MURAMYL DIPEPTIDE; IMMUNE-RESPONSES; HOST-DEFENSE; IPAF; RECEPTOR; INFECTION;
D O I
10.1002/eji.200940180
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Members of the Nod-like receptor family and the adaptor ASC assemble into multiprotein platforms, termed inflammasomes, to mediate the activation of caspase-1 and subsequent secretion of IL-1 beta and IL-18. Recent studies have identified microbial and endogenous molecules as well as possible mechanisms involved in inflammasome activation.
引用
收藏
页码:611 / 615
页数:5
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