Increased platelet Fc receptor expression as a potential contributing cause of platelet hypersensitivity to collagen in diabetes mellitus

被引：44

作者：

Calverley, DC

Hacker, MR

Loda, KA

Brass, E

Buchanan, TA

Tsao-Wei, DD

Groshen, S

机构：

[1] Univ Colorado, Div Hematol, Denver, CO 80202 USA

[2] Univ Colorado, Mt States Reg Hemophilia & Thrombosis Ctr, Denver, CO 80202 USA

[3] Univ Colorado, Div Med Oncol, Denver, CO 80202 USA

[4] Univ So Calif, Sch Med, Div Hematol, Los Angeles, CA USA

[5] Univ So Calif, Sch Med, Div Endocrinol & Metab, Los Angeles, CA USA

[6] Univ So Calif, Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2003年 / 121卷 / 01期

关键词：

blood platelets; diabetes mellitus; cardiovascular disease; collagen; receptors; Fc;

D O I：

10.1046/j.1365-2141.2003.04233.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent clinical and laboratory observations support a potential role for the platelet FcgammaRIIA receptor (FcR) in collagen-mediated platelet activation associated with arterial thrombosis. Stable age- and sex-independent variation in receptor expression exists. Flow cytometry showed that 100 diabetes patients had increased mean platelet FcR expression levels compared with 201 non-diabetes patients (P < 0.001). Aggregation studies following FcR cross-linking supported a receptor role in increased activation of diabetes platelets after collagen stimulation (P = 0.018). Immunoprecipitation of collagen-stimulated and FcR-crosslinked platelets demonstrated enhanced levels of tyrosine-phosphorylated Syk in diabetic platelets. Increased platelet FcR-mediated sensitivity to collagen may contribute to cardiovascular morbidity and mortality in diabetes.

引用

页码：139 / 142

页数：4

共 12 条

[1] Potential role of platelet FcγRIIA in collagen-mediated platelet activation associated with atherothrombosis [J].